The Comparison of Hypertonic Saline and Normal Saline Nasal Spray to Relieve Short-Term Nasal Congestion in Allergic Rhinitis

Phase 2

Completed

• Conditions: Allergic rhinitis in adult; allergic rhinitis, nasal congestion, nasal spray, hypertonic saline

• Registration Number: TCTR20200317004
• Lead Sponsor: Faculty of Medicine Siriraj Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-10-31
• Study Start: 2020-03-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

(1) age 18-60 years, (2) diagnosed AR from history, physical examination and positive skin prick test, intradermal test or specific IgE, (3) congestion score from TNSS ≥ 2 at this visit and VAS of congestion > 4 at this visit

Exclusion Criteria

(1) nasal anatomic defects such as moderate to severe deviated nasal septum18, nasal polyp or tumor, (2) mucociliary clearance defects such as cystic fibrosis, (3) history of sinonasal surgery, (4) upper or lower respiratory tract infection in the preceding 1 week, (5) active smoker, (6) use of systemic steroid, oral/topical decongestant or antihypertensive drug.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
asal congestion symptom pre-dose, at 5 and 15 minute post-dose total nasal symptom score, visual analog scale

Secondary Outcome Measures

Name	Time	Method
peak nasal inspiratory flow, nasal airway resistant pre-dose, at 5 and 15 minute post-dose nasal flow meter, rhinomanometry