Pessary or Progesterone to Prevent Preterm delivery in women with a twin pregnancy and short cervical length

Not Applicable

• Conditions: Short cervix in twin pregnancy; Reproductive Health and Childbirth - Antenatal care; Reproductive Health and Childbirth - Fetal medicine and complications of pregnancy

• Registration Number: ACTRN12616000875404
• Lead Sponsor: Women's and Children's Health Network

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Female
• Target Recruitment: 140

Inclusion Criteria

Viable twin pregnancy
Cervical length less than 38mm via transvaginal ultrasound assessment

Exclusion Criteria

Placenta praevia
Cervical cerclage in this pregnancy
Identified major congenital anomaly
Demise of one or both twins
previous preterm birth (including of singleton)
Previous participation in the Quad P-twin study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite adverse neonatal outcome icluding periventricular leukomalacia (PVL) > grade 1, severe respiratory distress syndrome (RDS) bronchopulmonary Dyplasia (BPD), Intraventricular Haemorrhage grade III or IV, Necrotizing Enterocolitis (NEC) > stage 1, proven sepsis, (intrapartum) stillbirth and death before discharge from the nursery. These will be assessed by review of medical records.[Time of delivery]

Secondary Outcome Measures

Name	Time	Method
Time to delivery<br>Preterm birth rates at 38, 32, 34, and 37 weeks gestation. <br>These will be assessed by medical record review[Time of delivery]