Comparison of three desensitizing agents in reduction of dentinal hypersensitivity an in vivo study
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- considering thedropout rate of 10 percent the sample size will be 78 and outcome is to comapre and evaluate the efficacy of densitizing agent in reduction of dentinal hypersensitivity.
研究概览
简要总结
Aim: The aim of this in vivo study was to compare the efficacy of three desensitizing agents in reducing dentinal hypersensitivity. The investigation focused on assessing the immediate and lasting effects of the three agents on alleviating discomfort associated with dentinal hypersensitivity.
Methods: A randomized controlled trial was conducted on a cohort of patients presenting with dentinal hypersensitivity. In this study, a total of 25 patients with at least three teeth exhibiting dentin hypersensitivity (78 teeth in total) were assessed. Three groups were randomly assigned to receive different treatments for the teeth: Group 1 received D/Sense Crystal treatment, Group 2 received Fluorprotector vivampuole therapy, and Group 3 received Single Bond Universal dentin bonding agent. Using a visual analogue scale (VAS), dentin hypersensitivity levels were measured based on the patients’ reactions to touch, air blast, and cold water stimuli. Before and after treatment, at particular intervals (one, seven, fourteen, sixty, and ninety days), pain levels were noted.
Results: Initially, the baseline sensitivity measurements were similar across the three groups (Group-1: 9.2 ± 0.35, Group-2: 8.8 ± 0.46, Group-3: 8.9 ± 0.39) with a non-significant p-value of 0.15. However, significant differences in sensitivity reduction were observed immediately after treatment, with Group-3 exhibiting the most substantial decrease (5.3 ± 0.43) and Group-2 showing a moderate reduction (6.5 ± 0.45) with a p-value of 0.03. Over the 1-week, 1-month, and 3-month follow-ups, although differences persisted, they were not statistically significant (p-values of 0.09, 0.12, and 0.45, respectively). This study underscores the variable impacts of the dental agents on sensitivity reduction, emphasizing the need to consider both short-term and long-term effects when assessing dental treatments.
Conclusion: To summarize, this clinical trial successfully showcased a considerable reduction in dentin hypersensitivity (DH) across all three groups, with no reported side effects. After a single direct topical treatment, the Single Bond Universal dentin bonding agent administration resulted in an initial decrease in DH. Notably, at the 3-month follow-up, comparable DH scores were observed among all three groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- Double
入排标准
- 年龄范围
- 25.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients who had a maximum of two non-adjacent teeth with no cervical caries.
- •Patients with good oral hygiene.
- •Patients with complete general health.
- •Patients who agreed to participate in this 3-month study.
排除标准
- •Patients who had systemic diseases and/or psychologic disorders, or previous hospitalization and females who are pregnant.
- •Teeth with caries, cracks, or fracture at their cervical margin.
- •Teeth with extensive or faulty restorations, prostheses, or orthodontic appliances.
- •Substance abusers and patients taking analgesics and/or anti-inflammatory drugs.
- •Patients with a history of using desensitizing agents.
- •Patients who had allergy to materials used in the study.
- •Patients who did not consent to participation.
- •Patients who did not attend the follow-up.
结局指标
主要结局
considering thedropout rate of 10 percent the sample size will be 78 and outcome is to comapre and evaluate the efficacy of densitizing agent in reduction of dentinal hypersensitivity.
时间窗: IMMEDIATE, 1 WEEK,1 MONTH ,3 MONTHS
次要结局
- to clinically evaluate the reduction of dentinal hypersensitivity and evaluation of prognosis of the treatment(2 months, 3 months.)
研究者
Thanima Chandran
DR.RAJESH RAMDASJI KAMBE DENTAL COLLEGE AND HOSPITAL