Does Indoxyl Sulfate Have a Role in Uremic Pruritus?
- Conditions
- Pruritus
- Interventions
- Dietary Supplement: Uremic pateints with itching
- Registration Number
- NCT05634083
- Lead Sponsor
- Benha University
- Brief Summary
Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.
- Detailed Description
Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Patients with end-stage renal failure with itching undergoing regular hemodialysis
Patients with other causes of itching as psoriasis, atopic dermatitis, scabies, and lichen planus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Uremic Pateints group Uremic pateints with itching Patients with end-stage renal failure with itching
- Primary Outcome Measures
Name Time Method Severity of itching Two months Change of severity of itching by The Visual Analogue Scale score
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Faculty of Medicine, Benha University
🇪🇬Al Qalyūbīyah, Benha, Egypt
Benha University Hospitals
🇪🇬Banhā, Egypt