NCT05800093进行中（未招募）不适用
Proteomics and Genomics Combined With CT to Predict CVD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)1 个研究点 分布在 1 个国家目标入组 310 人开始时间: 2023年1月12日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 310
- 试验地点
- 1
- 主要终点
- Coronary Artery Disease Progression
研究概览
简要总结
This study evaluates plaque progression and characteristics in patients with coronary atherosclerosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients between 50 and 75 years old
- •Subjects at intermediate to high risk for ASCVD
- •Asymptomatic patients without cardiac chest pain
- •Evidence of atherosclerosis on baseline CCTA
排除标准
- •Renal insufficiency, defined as eGFR < 30 ml/min
- •History of cardiovascular events (myocardial infarction, peripheral artery disease and ischemic stroke)
- •Use of lipid lowering therapy other than statin, ezetimibe or bempedoic acid monotherapy
- •Change in lipid lowering therapy in the last 6 months
- •Use of more than two antihypertensive agents
- •No coronary atherosclerosis at baseline imaging
- •Active malignancy requiring treatment
- •Atrial fibrillation
- •Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
- •Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.
结局指标
主要结局
Coronary Artery Disease Progression
时间窗: Through study completion, between 130-156 weeks
次要结局
- Presence of obstructive stenosis(Through study completion, between 130-156 weeks)
- Calcified plaque volume progression(Through study completion, between 130-156 weeks)
- Change in Pericoronary Adipose Tissue CT-Attenuation(Through study completion, between 130-156 weeks)
- Non-calcified plaque volume progression(Through study completion, between 130-156 weeks)
- Progression in number of high-risk plaque characteristics (yes/no)(Through study completion, between 130-156 weeks)
- Progression in number of significant (>50%) and severe (>70%) stenoses(Through study completion, between 130-156 weeks)
- Total plaque volume progression(Through study completion, between 130-156 weeks)
- Low-attenuation plaque volume progression(Through study completion, between 130-156 weeks)
- CAD-RADS progression (yes/no)(Through study completion, between 130-156 weeks)
研究者
E.S.stroes
Principal Investigator
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
研究点 (1)
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