A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA)
- Conditions
- Ulcerative ColitisCrohn's Disease
- Interventions
- Drug: 25 mg OntamalimabDrug: 75 mg Ontamalimab
- Registration Number
- NCT03283085
- Lead Sponsor
- Shire
- Brief Summary
The purpose of this study is to evaluate the safety and tolerability of long-term treatment with ontamalimab in participants with moderate to severe Ulcerative Colitis (UC) or Crohn's disease (CD)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 557
Participants with Ulcerative Colitis (UC):
-
Participants and/or their parent or legally authorized representative must have an understanding, ability, and willingness to fully comply with study procedures and restrictions.
-
Participants must be able to voluntarily provide written, signed, and dated (personally or via a legally authorized representative) informed consent and/or assent, as applicable, to participate in the study.
-
Participants must have been enrolled previously in study SHP647-301 (NCT03259334), SHP647-302 (NCT03259308), and are in the treatment period of Study SHP647-303, completed the early termination (ET) or Week 52 visit in maintenance study SHP647-303 (NCT03290781), had responded to ontamalimab treatment (in the induction and/or maintenance studies), and meet one of the following criteria:
a. Participants are on placebo at the maintenance study ET or Week 52 visit: they received ontamalimab in the induction studies and fulfilled the maintenance study response criteria, OR b. Participants have received ontamalimab at the maintenance study ET or Week 52 visit: i) Clinical composite score that has decreased by >or=2 points and >or=30%, with an accompanying decrease in the subscore for RB >or=1 point or a subscore for RB <or=1, compared to the baseline value for induction studies, and/or ii) Composite score that has decreased by >or=30% and >or=3 points compared to the baseline value for induction studies.
-
Participants receiving any treatment(s) for UC are eligible provided they have been on a stable dose for the designated period of time.
Participants with Crohn's Disease:
-
Participants and/or their parent or legally authorized representative must have an understanding, ability, and willingness to fully comply with study procedures and restrictions.
-
Participants must be able to voluntarily provide written, signed, and dated (personally or via a legally authorized representative) informed consent and/or assent, as applicable, to participate in the study.
-
Participants must have been enrolled previously in Study SHP647-305 (NCT03559517) or SHP647-306 (NCT03566823) and are in the treament period of Study SHP647-307 (NCT03627091), completed the ET or Week 52 visit in maintenance study SHP647-307, had responded to ontamalimab treatment (in the induction or maintenance studies) and meet one of the following criteria:
- Participants are on placebo at the maintenance study ET or Week 52 visit: they received ontamalimab in the induction study and fulfilled the maintenance study response criteria, OR
- Participants have received ontamalimab at the maintenance study ET or Week 52 visit:
i) CDAI score that has decreased by >or=100 points at EOT visit compared to the baseline value for induction studies, and/or ii) SES-CD that has decreased by >or=25% compared to the baseline value for induction studies.
-
Participants receiving any treatment(s) for CD are eligible provided they have been on a stable dose for the designated period of time.
Participants with UC:
- Participants who had major protocol deviation(s) (as determined by the sponsor) in study SHP647-301, SHP647-302, or SHP647-303.
- Participants who permanently discontinued investigational product because of an AE, regardless of relatedness to investigational product, in study SHP647-301, SHP647-302, or SHP647-303.
- Participants who are likely to require major surgery for UC.
- Participants are females who became pregnant during study SHP647-301, SHP647-302, or SHP647-303, females who are lactating, females who are planning to become pregnant during the study period, or males or females of childbearing potential not agreeing to continue using appropriate contraception methods (i.e. highly effective methods for female and medically appropriate methods for male study participants) through the conclusion of study participation.
- Participants who do not agree to postpone donation of any organ or tissue, including male participants who are planning to bank or donate sperm and female participants who are planning to harvest or donate eggs, for the duration of the study and through 16 weeks after last dose of investigational product.
- Participants who, in the opinion of the investigator or the sponsor, will be uncooperative or unable to comply with study procedures.
- Participants who have a newly-diagnosed malignancy or recurrence of malignancy (other than resected cutaneous basal cell carcinoma, squamous cell carcinoma, or carcinoma in situ of the uterine cervix that has been treated with no evidence of recurrence).
- Participants who have developed any major illness/condition or evidence of an unstable clinical condition (example [e.g.], renal, hepatic, hematologic, gastrointestinal [except disease under study], endocrine, cardiovascular, pulmonary, immunologic [e.g. Felty's syndrome], or local active infection/infectious illness) that, in the investigator's judgment, will substantially increase the risk to the participant if he or she participates in the study.
- Participants with any other severe acute or chronic medical or psychiatric condition or laboratory or ECG abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study.
- Participants with known exposure to Mycobacterium tuberculosis (TB) since testing at screening in study SHP647-301 (NCT03259334) or SHP647-302 (NCT03259308) and who have been advised to require treatment for latent or active disease, but who are without a generally accepted course of treatment.
- Participants who are investigational site staff members or relatives of those site staff members or participants who are sponsor employees directly involved in the conduct of the study.
- Participants who are participating in other investigational studies (other than SHP647-301, SHP647-302, or SHP647-303) or plan to participate in other investigational studies during long-term extension study SHP647-304.
Participants with Crohn's Disease:
- Participants who had major protocol deviation(s) (as determined by the sponsor) in study SHP647-305, SHP647-306 or SHP647-307.
- Participants who permanently discontinued investigational product because of an adverse events (AE), regardless of relatedness to investigational product, in study SHP647-305, SHP647-306 or SHP647-307.
- Participants who are likely to require major surgery for CD or developed acute severe complications of CD (with or without fulfilling the treatment failure criteria in the maintenance study) that required immediate intervention (e.g. need for immediate biologic treatment with proven effect) and/or Crohn's Disease Activity Index (CDAI) score more than (>) 450.
- Participants are females who became pregnant during study SHP647-305, SHP647-306 or SHP647-307, females who are lactating, females who are planning to become pregnant during the study period, or males or females of childbearing potential not agreeing to continue appropriate contraception methods (i.e. highly effective methods for female and medically appropriate methods for male study participants) through the conclusion of study participation.
- Participants who do not agree to postpone donation of any organ or tissue, including male participants who are planning to bank or donate sperm and female participants who are planning to harvest or donate eggs, for the duration of the study and through 16 weeks after last dose of investigational product.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description UC: Ontamalimab 25mg then 75 mg 25 mg Ontamalimab Participants received 25 mg of ontamalimab solution for injection SC, Q4W, and later progressed to receive 75 mg in a similar manner for up to 5.79 years. CD: Ontamalimab 75 mg 75 mg Ontamalimab Participants received 75 mg of ontamalimab solution for injection SC, Q4W, for up to 5.79 years. CD: Ontamalimab 25mg then 75 mg 75 mg Ontamalimab Participants received 25 mg of ontamalimab solution for injection SC, Q4W, and later progressed to receive 75 mg in a similar manner for up to 5.79 years. Ulcerative Colitis (UC): Ontamalimab 25 mg 25 mg Ontamalimab Participants received 25 milligrams (mg) of ontamalimab solution for injection subcutaneously (SC), every 4 weeks (Q4W), for up to 3 years. UC: Ontamalimab 25mg then 75 mg 75 mg Ontamalimab Participants received 25 mg of ontamalimab solution for injection SC, Q4W, and later progressed to receive 75 mg in a similar manner for up to 5.79 years. Crohn's disease (CD): Ontamalimab 25 mg 25 mg Ontamalimab Participants received 25 mg of ontamalimab solution for injection SC, Q4W, for up to 3 years. UC: Ontamalimab 75 mg 75 mg Ontamalimab Participants received 75 mg of ontamalimab solution for injection SC, Q4W, for up to 5.79 years. CD: Ontamalimab 25mg then 75 mg 25 mg Ontamalimab Participants received 25 mg of ontamalimab solution for injection SC, Q4W, and later progressed to receive 75 mg in a similar manner for up to 5.79 years.
- Primary Outcome Measures
Name Time Method Number of Participants With Treatment Emergent Adverse Events (TEAEs) From first dose of study drug up to end of study [EOS] (up to 5.79 years) An adverse event (AE) was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. Treatment-emergent AEs (TEAEs) were defined as AEs with start dates or worsening dates at the time of or following the first exposure to investigational product.
Number of Participants With Discernible Changes in Vital Signs Over Time From first dose of study drug up to EOS (up to 5.79 years) Vital sign assessments included blood pressure, pulse, respiratory rate, and temperature. Any discernible changes in vital signs over time per investigator interpretation were reported.
Number of Participants With Serious Infections From first dose of study drug up to EOS (up to 5.79 years) Serious infections were defined as any infections that were life-threatening or those requiring hospitalization or intravenous antibiotics based on the investigator's assessment.
Number of Participants With Notable Changes in Clinical Laboratory Parameters Over Time From first dose of study drug up to EOS (up to 5.79 years) Clinical laboratory assessments included hematology, serum chemistry and urinalysis. Any notable changes in the clinical laboratory value over time based on the investigator interpretation were reported.
Number of Participants With Discernible Changes in Electrocardiogram (ECG) Over Time From first dose of study drug up to EOS (up to 5.79 years) ECG included heart rhythm, heart rate, QRS intervals, QT intervals, RR intervals and corrected QT (QTc) intervals parameters measurement. Any discernible changes in the ECG value over time based on investigator interpretation were reported.
- Secondary Outcome Measures
Name Time Method Number of Participants With Ulcerative Colitis With Treatment Response Over Time Up to 5.79 years Treatment response over time was defined as clinical composite score that has decreased by greater than or equal to (≥2) points and ≥30 percentage (%), with an accompanying decrease in the sub score for rectal bleeding (RB) ≥1 point or a subscore for RB ≤ 1, and/or composite score that has decreased by ≥30% and ≥3 points compared to the baseline value for induction studies. The clinical composite score is a measure consisting of sub scores RB (0-3) plus stool frequency (0-3) with higher scores indicating more severe disease. With the implementation of amendment 4 of the protocol the study became a single arm study with all participants receiving the 75 mg dose of ontamalimab. Hence, only those UC participants who were receiving the 75 mg dose of ontamalimab every 4 weeks and participating in amendment 4 of the protocol were analyzed in this outcome measure.
Number of Participants With Crohn's Disease With Treatment Response Over Time Up to 5.79 years Treatment response over time=Crohn's Disease Activity Index(CDAI)score that has decreased ≥100 points and/or simple endoscopic score for Crohn's disease(SES-CD)that has decreased by ≥25%,both compared to baseline value for induction studies.SES-CD is simple scoring system with 4 endoscopic variables measured in same 5 ileocolonic segments as CD index of severity. Overall values on SES-CD range from 0-56,higher values=more severe disease.4 endoscopic variables are scored from 0-3 in each bowel segment:ileum,right/transverse/left colon,rectum. Presence \& size of ulcers(none=0;diameter 0.1-0.5centimeter(cm)=1;0.5-2cm=2;\>2cm=3);extent of ulcerated surface(none=0;\<10%=1;10%-30%=2; \>30%= 3);extent of affected surface(none=0;\<50%=1;50%-75%=2;\>75%=3);Presence \& type of narrowing (none=0;single can be passed=1;multiple can be passed=2;cannot be passed=3).
Trial Locations
- Locations (413)
Arizona Digestive Health Mesa - East
🇺🇸Mesa, Arizona, United States
SIH Research
🇺🇸Kissimmee, Florida, United States
BRCR Medical Center, Inc
🇺🇸Plantation, Florida, United States
Penn State Hershey Medical Group
🇺🇸State College, Pennsylvania, United States
Percuro Clinical Research LTD
🇨🇦Victoria, British Columbia, Canada
Veterans Research Foundation of Pittsburgh - NAVREF - PPDS
🇺🇸Pittsburgh, Pennsylvania, United States
Precision Research Institute, LLC
🇺🇸Houston, Texas, United States
Biopharma Informatic Inc.
🇺🇸Houston, Texas, United States
Aztec Medical Research
🇺🇸Houston, Texas, United States
Biopharma Informatic Research Center
🇺🇸Houston, Texas, United States
Advanced Clinical Research Network
🇺🇸Miami, Florida, United States
Advanced Biomedical Research of America
🇺🇸Las Vegas, Nevada, United States
Gastro Health Research
🇺🇸Cincinnati, Ohio, United States
Theageneio Anticancer Oncology Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
University of California San Diego
🇺🇸La Jolla, California, United States
Weill Cornell Medical College
🇺🇸New York, New York, United States
Piedmont Healthcare
🇺🇸Statesville, North Carolina, United States
Centro de Investigacion Clinica Acelerada, S.C.
🇲🇽Tepeyac Insurgentes, Distrito Federal, Mexico
Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V.
🇲🇽Zapopan, Jalisco, Mexico
Clinica de Higado y Gastroenterologia Integral, S.C.
🇲🇽Cuernavaca, Morelos, Mexico
East Viru Central Hospital
🇪🇪Kohta-Järve, Estonia
St Vincent's University Hospital
🇮🇪Dublin, Ireland
Fundación Valle Del Lili
🇨🇴Cali, Valle Del Cauca, Colombia
Clinical Center Banja Luka
🇧🇦Banja Luka, Bosnia and Herzegovina
Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
🇲🇽Durango, Mexico
Accelerium, S. de R.L. de C.V. - PPDS
🇲🇽Monterrey, Nuevo León, Mexico
Klinikum Wels-Grieskirchen GmbH
🇦🇹Wels, Austria
Vilnius City Clinical Hospital
🇱🇹Vilnius, Lithuania
Phylasis Clinicas Research S. de R.L. de C.V.
🇲🇽Cuautitlán Izcalli, Mexico
Gastro LM, s.r.o.
🇸🇰Presov, Slovakia
Vilnius University Hospital Santaros Klinikos
🇱🇹Vilnius, Lithuania
Centro de Investigación Médica Aguascalientes
🇲🇽Aguascalientes, Mexico
Uniwersytecki Szpital Kliniczny w Bialymstoku
🇵🇱Bialystok, Podlaskie, Poland
University Clinical Center Nis
🇷🇸Nis, Serbia
Servimed S.A.S
🇨🇴Bucaramanga, Santander, Colombia
Gastromedica SRL
🇷🇴Iasi, Romania
Clinical Research Institute
🇲🇽Tlalnepantla De Baz, Mexico
Colentina Clinical Hospital
🇷🇴Bucharest, Romania
Emergency University Hospital
🇷🇴Bucharest, Romania
SC Centrul Medical MEDICUM S.R.L.
🇷🇴Bucuresti, Romania
JM Research S.C
🇲🇽Cuernavaca, Morelos, Mexico
Prof. Dr. Matei Bals Institute of Infectious Diseases
🇷🇴Bucharest, Romania
Fundeni Clinical Institute
🇷🇴Bucharest, Romania
Cluj-Napoca Emergency Clinical County Hospital
🇷🇴Cluj-Napoca, Romania
Clinical Hospital Center Bezanijska Kosa
🇷🇸Belgrade, Serbia
General Hospital Vrsac
🇷🇸Vrsac, Serbia
University Clinical Center Kragujevac
🇷🇸Kragujevac, Šumadijski Okrug, Serbia
Univerzitna nemocnica Bratislava
🇸🇰Bratislava, Slovakia
Royal Shrewsbury Hospital
🇬🇧Shrewsbury, Shropshire, United Kingdom
Fairfield General Hospital - PPDS
🇬🇧Lancashire, Bury, United Kingdom
North Tyneside General Hospital
🇬🇧North Shields, Northumberland, United Kingdom
University of California San Francisco
🇺🇸San Francisco, California, United States
Encompass Care
🇺🇸North Las Vegas, Nevada, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Southern Star Research Institute LLC
🇺🇸San Antonio, Texas, United States
Elite Clinical Studies - Phoenix - Clinedge - PPDS
🇺🇸Phoenix, Arizona, United States
Veteran's Research and Education Foundation - NAVREF - PPDS
🇺🇸Oklahoma City, Oklahoma, United States
UMass Memorial Medical Center
🇺🇸Worcester, Massachusetts, United States
Minnesota Gastroenterology PA
🇺🇸Saint Paul, Minnesota, United States
Pharma Research International Inc
🇺🇸Naples, Florida, United States
Edward Hines Jr VA Hospital - NAVREF - PPDS
🇺🇸Hines, Illinois, United States
East Coast Institute for Research, LLC
🇺🇸Saint Augustine, Florida, United States
St Louis Center For Clinical Research
🇺🇸Saint Louis, Missouri, United States
OM Research LLC - Lancaster - ClinEdge - PPDS
🇺🇸Lancaster, California, United States
Facey Medical Foundation
🇺🇸Mission Hills, California, United States
Crystal Biomedical Research
🇺🇸Miami Lakes, Florida, United States
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
United Medical Doctors
🇺🇸Murrieta, California, United States
Hi Tech and Global Research, LLc
🇺🇸Miami, Florida, United States
Sanchez Clinical Research, Inc
🇺🇸Miami, Florida, United States
Advanced Research Center
🇺🇸Anaheim, California, United States
Infinite Clinical Trials
🇺🇸Morrow, Georgia, United States
CATS Research Center - University of Arizona
🇺🇸Tucson, Arizona, United States
Tibor Rubin VA Medical Center - NAVREF
🇺🇸Long Beach, California, United States
National Clinical, LLC
🇺🇸Hamtramck, Michigan, United States
NYU Langone Long Island Clinical Research Associates
🇺🇸Great Neck, New York, United States
Alliance Medical Research LLC
🇺🇸Coral Springs, Florida, United States
Alliance Clinical Research-(Vestavia Hills)
🇺🇸Poway, California, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
VA Long Beach Healthcare System - NAVREF - PPDS
🇺🇸Long Beach, California, United States
Gastroenterology Associates of Hazard
🇺🇸Hazard, Kentucky, United States
Gastroenterology Associates of Western Michigan, PLC
🇺🇸Wyoming, Michigan, United States
Accel Research Sites - St. Petersburg - ERN - PPDS
🇺🇸Pinellas Park, Florida, United States
Inland Empire Liver Foundation
🇺🇸Rialto, California, United States
Renaissance Research Medical Group, INC
🇺🇸Cape Coral, Florida, United States
Gastrointestinal Diseases, Inc Research - IACT- HyperCore - PPDS
🇺🇸Columbus, Georgia, United States
Laporte County Institute For Clinical Research
🇺🇸Michigan City, Indiana, United States
CroNOLA, LLC.
🇺🇸Houma, Louisiana, United States
Louisiana Research Center LLC
🇺🇸Shreveport, Louisiana, United States
Medisphere Medical Research Center LLC
🇺🇸Evansville, Indiana, United States
East Carolina Gastroenterology
🇺🇸Jacksonville, North Carolina, United States
IL Gastroenterology Group
🇺🇸Gurnee, Illinois, United States
Dupage Medical Group
🇺🇸Oakbrook Terrace, Illinois, United States
Advanced Gastroenterology-Union City
🇺🇸Union City, Tennessee, United States
Mayo Clinic Health System - PPDS
🇺🇸Duluth, Minnesota, United States
Mid Atlantic Health Specialists
🇺🇸Galax, Virginia, United States
Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Commonwealth Clinical Studies LLC
🇺🇸Brockton, Massachusetts, United States
Digestive Health Center PA
🇺🇸Ocean Springs, Mississippi, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Ohio Clinical Research Partners LLC
🇺🇸Mentor, Ohio, United States
Northside Gastroenterology
🇺🇸Cypress, Texas, United States
A.ö. Krankenhaus der Barmherzigen Brüder
🇦🇹St. Veit an der Glan, Kärnten, Austria
Universitätsklinikum St. Pölten
🇦🇹St. Pölten, Austria
CHU Mouscron
🇧🇪Mouscron, Belgium
Prestige Clinical Research
🇺🇸Franklin, Ohio, United States
Medical Center Convex EOOD
🇧🇬Sofia, Bulgaria
Digestive Disease Associates
🇺🇸Wyomissing, Pennsylvania, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
CHI Franciscan Digestive Care Associates
🇺🇸Tacoma, Washington, United States
Mater Hospital Brisbane
🇦🇺South Brisbane, Queensland, Australia
Opca Bolnica Karlovac
🇭🇷Karlovac, Karlovacka Županija, Croatia
Clinical Hospital Centre Osijek
🇭🇷Osijek, Croatia
Winchester Gastroenterology Associates
🇺🇸Winchester, Virginia, United States
University Multiprofile Hospital for Active Treatment - Dr. Georgi Stranski EAD
🇧🇬Pleven, Bulgaria
DM Clinical Research - ERN - PPDS
🇺🇸Tomball, Texas, United States
Fundación Favaloro
🇦🇷Buenos Aires, Argentina
Medical Center-1-Sevlievo EOOD
🇧🇬Sevlievo, Bulgaria
Inquest Clinical Research/Coastal Gastroenterology Associates, PA - TDDC - PPDS
🇺🇸Webster, Texas, United States
Sanatorio 9 de Julio SA
🇦🇷San Miguel de Tucumán, Argentina
Southwest Clinical Trials
🇺🇸Houston, Texas, United States
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Medical Center Excelsior OOD - PPDS
🇧🇬Sofia, Bulgaria
Klinikum Klagenfurt Am Woerthersee
🇦🇹Klagenfurt am Wörthersee, Austria
Salzburger Landeskliniken
🇦🇹Salzburg, Austria
Hospital Privado Centro Médico de Córdoba
🇦🇷Córdoba, Argentina
Multiprofile Hospital for Active Treatment Eurohospital
🇧🇬Plovdiv, Bulgaria
Institut Klinicke A Experimentalni Mediciny
🇨🇿Praha 4, Czechia
LKH-Universitätsklinikum Klinikum Graz
🇦🇹Graz, Steiermark, Austria
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Medizinische Universitat Wien (Medical University of Vienna)
🇦🇹Wien, Austria
Hospital Pablo Tobón Uribe
🇨🇴Medellin, Antioquia, Colombia
General County Hospital Vukovar and Croatian Veterans Hospital
🇭🇷Vukovar, Croatia
UZ Gent
🇧🇪Gent, Oost-Vlaanderen, Belgium
Royal Brisbane & Women's Hospital
🇦🇺Herston, Queensland, Australia
AZ Groeninge
🇧🇪Kortrijk, West-Vlaanderen, Belgium
Acibadem City Clinic University Multiprofile Hospital for Active Treatment EOOD
🇧🇬Sofia, Sofia-Grad, Bulgaria
Hepato-Gastroenterologie HK, s. r. o.
🇨🇿Hradec Králové, Královéhradecký Kraj, Czechia
The Alfred Hospital
🇦🇺Box Hill, Victoria, Australia
Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z.
🇨🇿Usti nad Labem, Czechia
Euromedica - PPDS
🇬🇷Thessaloniki, Greece
IPS Centro Médico Julián Coronel S.A.S. - PPDS
🇨🇴Cali, Colombia
Jikei University Hospital
🇯🇵Minato-ku, Tokyo, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Tokyo, Japan
Tolna Megyei Balassa János Kórház
🇭🇺Szekszard, Hungary
Magyar Honvédség Egészségügyi Központ
🇭🇺Budapest, Hungary
Universitatsklinikum Schleswig-Holstein
🇩🇪Kiel, Schleswig-Holstein, Germany
OÜ LV Venter
🇪🇪Pärnu, Pärnumaa, Estonia
Nihonbashi Egawa Clinic
🇯🇵Chuo-Ku, Tokyo, Japan
Sana Klinikum Biberach
🇩🇪Biberach an der Riss, Germany
Mohacsi Korhaz
🇭🇺Mohacs, Hungary
Charité - Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Bekes Megyei Kozponti Korhaz
🇭🇺Gyula, Hungary
Pannónia Magánorvosi Centrum Kft
🇭🇺Budapest, Hungary
ISCARE I.V.F. a.s.
🇨🇿Praha 7, Czechia
Nemocnice Pardubickeho kraje, a.s. Orlickoustecka nemocnice
🇨🇿Usti nad Orlici, Czechia
Azienda Ospedaliera San Camillo Forlanini
🇮🇹Roma, Lazio, Italy
Ippokrateio General Hospital of Athens
🇬🇷Athens, Attiki, Greece
Iatriko Palaiou Falirou
🇬🇷Paliao Faliro, Greece
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Toscana, Italy
Hyogo College of Medicine
🇯🇵Nishinomiya-shi, Hyôgo, Japan
ENDOMEDIX Kft.
🇭🇺Budapest, Hungary
Baruch Padeh Poriya Medical Center
🇮🇱Tiberias, Israel
Universitätsklinikum Ulm
🇩🇪Ulm, Baden-Württemberg, Germany
Kunimoto Hospital
🇯🇵Asahikawa, Japan
Tel Aviv Sourasky Medical Center PPDS
🇮🇱Tel Aviv, Israel
IRCCS Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar, Veneto, Italy
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
University General Hospital of Heraklion
🇬🇷Heraklion, Greece
Ome Municipal General Hospital
🇯🇵Ome, Tokyo, Japan
Azienda Ospedaliera Città della Salute e della Scienza di Torino
🇮🇹Torino, Italy
Azienda Ospedaliera Mater Domini Di Catanzaro
🇮🇹Catanzaro, Calabria, Italy
Universitätsklinikum Frankfurt
🇩🇪Frankfurt, Germany
Gastro Campus Research GbR
🇩🇪Münster, Nordrhein-Westfalen, Germany
Csolnoky Ferenc Korhaz
🇭🇺Veszprém, Hungary
Sapporo Tokushukai Hospital
🇯🇵Sapporo-shi, Hokkaidô, Japan
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Sagamihara Kyodo Hospital
🇯🇵Sagamihara, Kanagawa, Japan
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
🇭🇺Székesfehérvár, Hungary
Aichi Medical University Hospital
🇯🇵Nagakute, Japan
Galilee Medical Center
🇮🇱Nahariya, Israel
Hadassah Medical Center - PPDS
🇮🇱Jerusalem, Israel
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi
🇮🇹Bologna, Emilia-Romagna, Italy
Csongrad Megyei Dr. Bugyi Istvan Korhaz
🇭🇺Szentes, Hungary
Tokatsu Tsujinaka Hospital
🇯🇵Abiko, Japan
Centrum Diagnostyczno - Lecznicze Barska sp. z o.o.
🇵🇱Wloclawek, Kujawsko-pomorskie, Poland
VU Medisch Centrum
🇳🇱Amsterdam, Netherlands
Samsung Medical Center PPDS
🇰🇷Seoul, Korea, Republic of
Kawabe Clinic
🇯🇵Koganei, Japan
Aizawa Hospital
🇯🇵Matsumoto-shi, Japan
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Hammoud Hospital University Medical Center
🇱🇧Saida, Lebanon
Severance Hospital Yonsei University Health System - PPDS
🇰🇷Seoul, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Kyungpook National University Hospital
🇰🇷Daegu, Daegu Gwang'yeogsi, Korea, Republic of
Al Zahraa University Hospital
🇱🇧Beirut, Lebanon
Koukokukai Ebisu Clinic
🇯🇵Tokyo, Japan
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju, Gang'weondo, Korea, Republic of
Waikato Hospital
🇳🇿Hamilton, New Zealand
Onomichi General Hospital
🇯🇵Onomichi, Japan
Rafik Hariri University Hospital
🇱🇧Beirut, Lebanon
Lexmedica
🇵🇱Wroclaw, Dolnoslaskie, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Twoja Przychodnia SCM
🇵🇱Szczecin, Zachodniopomorskie, Poland
Centrum Medyczne Gdynia - PRATIA - PPDS
🇵🇱Gdynia, Poland
NZOZ All Medicus
🇵🇱Katowice, Poland
Yuai Memorial Hospital
🇯🇵Koga, Japan
Hidaka Coloproctology Clinic
🇯🇵Kurume-shi, Japan
Medical Corporation Shoyu-kai Fujita Gastroenterology Hospital
🇯🇵Takatsuki, Japan
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
BioVirtus Centrum Medyczne
🇵🇱Jozefow, Mazowieckie, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
🇵🇱Warszawa, Mazowieckie, Poland
Ishida Clinic of IBD and Gastroenterology
🇯🇵Oita-city, Ôita, Japan
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Dunedin Hospital
🇳🇿Dunedin, South Island, New Zealand
Wellington Hospital
🇳🇿Newtown, Wellington, New Zealand
Asan Medical Center - PPDS
🇰🇷Seoul, Korea, Republic of
Unidad de Atencion Medica e Investigacion en Salud
🇲🇽Merida, Yucatán, Mexico
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
Accelerium, S. de R.L. de C.V.
🇲🇽Monterrey, Mexico
Krakowskie Centrum Medyczne
🇵🇱Krakow, Malopolskie, Poland
Miedzyleski Szpital Specjalistyczny w Warszawie
🇵🇱Warszawa, Mazowieckie, Poland
Endoskopia Sp. z o.o.
🇵🇱Sopot, Pomorskie, Poland
Centrum Medyczne Bydgoszcz- PRATIA - PPDS
🇵🇱Bydgoszcz, Poland
Amsterdam UMC - Meibergdreef 9
🇳🇱Amsterdam, Netherlands
Shinbeppu Hospital
🇯🇵Beppu, Ôita, Japan
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Dr. Tirnaveanu Amelita Private Practice
🇷🇴Oradea, Romania
Niepubliczny Zaklad Opieki Zdrowotnej CENTRUM MEDYCZNE Szpital Swietej Rodziny
🇵🇱Lódz, Lódzkie, Poland
Kazan State Medical University
🇷🇺Kazan, Russian Federation
Hospital Senhora da Oliveira - Guimaraes, E.P.E
🇵🇹Guimarães, Portugal
Niepubliczny Zakład Opieki Zdrowotnej VIVAMED
🇵🇱Warszawa, Mazowieckie, Poland
Centro Hospitalar do Algarve - Hospital de Portimao
🇵🇹Faro, Portugal
Sonomed Sp. z o.o.
🇵🇱Szczecin, Poland
Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II
🇵🇱Zamosc, Poland
Hospital de São Bernardo
🇵🇹Setubal, Portugal
Hospital da Luz
🇵🇹Lisboa, Portugal
Sana Monitoring SRL
🇷🇴Bucharest, Romania
Clinical Hospital Center Zemun
🇷🇸Zemun, Serbia
Centro Medico Teknon - Grupo Quironsalud
🇪🇸Barcelona, Spain
Hospital Universitario La Paz - PPDS
🇪🇸Madrid, Spain
Communal Nonprofit Enterprise Vinnytsia Regional Clinical Hospital named after N.I. Pirogov VR
🇺🇦Vinnytsia, Vinnyts'ka Oblast, Ukraine
Western General Hospital Edinburgh - PPDS
🇬🇧Edinburh, United Kingdom
Ospedale Casa Sollievo Della Sofferenza IRCCS
🇮🇹San Giovanni Rotondo (FG), Puglia, Italy
A.O.U. Maggiore della Carità
🇮🇹Novara, Italy
La Sapienza-Università di Roma-Policlinico Umberto I
🇮🇹Roma, Italy
Fondazione IRCCS Policlinico San Matteo di Pavia
🇮🇹Pavia, Italy
Fondazione Policlinico Universitario A Gemelli
🇮🇹Roma, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano (MI), Italy
Bellland General Hospital
🇯🇵Sakai, Japan
Chiinkai Dojima General & Gastroenterology Clinic
🇯🇵Osaka, Japan
Nishinomiya Municipal Central Hospital
🇯🇵Nishinomiya, Japan
Kinshukai Infusion Clinic
🇯🇵Osaka-shi, Japan
Colo-Proctology Center Matsushima Clinic
🇯🇵Yokohama, Japan
Tohoku Rosai Hospital
🇯🇵Sendai, Japan
Yodogawa Christian Hospital
🇯🇵Osaka, Ôsaka, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Japan
Royal Gwent Hospital - PPDS
🇬🇧Newport, United Kingdom
Toronto Digestive Disease Associates Inc
🇨🇦Toronto, Ontario, Canada
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon, Gyeonggido, Korea, Republic of
Klinikum rechts der Isa der Technischen Universitaet Muenchen
🇩🇪Munich, Germany
Universitatsklinikum Jena
🇩🇪Jena, Thüringen, Germany
Universitätsklinikum der RWTH Aachen
🇩🇪Aachen, Nordrhein-Westfalen, Germany
Second Multiprofile Hospital for Active Treatment Sofia
🇧🇬Sofia, Bulgaria
Diagnostic and Consulting Center Aleksandrovska EOOD
🇧🇬Sofia, Bulgaria
Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases Dr.D.Gramatikov- Ruse- PPDS
🇧🇬Ruse, Bulgaria
University Multiprofile Hospital for Active Treatment Sv Ivan Rilski EAD
🇧🇬Sofia, Bulgaria
Diagnostic Consultative Centre Mladost - M OOD
🇧🇬Varna, Bulgaria
HP Clinical Research
🇺🇸Bountiful, Utah, United States
Cotton O'Neil Clinical Research Center
🇺🇸Topeka, Kansas, United States
St Vincents Hospital Melbourne - PPDS
🇦🇺Melbourne, Victoria, Australia
New York Total Medical Care PC
🇺🇸Brooklyn, New York, United States
Southtowns Gastroenterology, PLLC
🇺🇸Orchard Park, New York, United States
Jávorszky Ödön Kórház
🇭🇺Vác, Hungary
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
🇧🇬Sofia, Bulgaria
Arizona Digestive Health
🇺🇸Sun City, Arizona, United States
Atria Clinical Research - Clinedge - PPDS
🇺🇸Little Rock, Arkansas, United States
Care Access Research, San Pablo
🇺🇸San Pablo, California, United States
Kindred Medical Institute for Clinical Trials, LLC
🇺🇸Corona, California, United States
Asthma and Allergy Associates PC - CRN - PPDS
🇺🇸Colorado Springs, Colorado, United States
Gastro Florida
🇺🇸Clearwater, Florida, United States
ENCORE Borland-Groover Clinical Research - ERN - PPDS
🇺🇸Jacksonville, Florida, United States
Nuren Medical and Research Center
🇺🇸Miami, Florida, United States
Bayside Clinical Research - New Port Richey
🇺🇸New Port Richey, Florida, United States
DBC Research
🇺🇸Tamarac, Florida, United States
Atlanta Center For Gastroenterology PC
🇺🇸Decatur, Georgia, United States
Loretto Hospital
🇺🇸Chicago, Illinois, United States
Atlanta Gastroenterology Specialists, PC
🇺🇸Suwanee, Georgia, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Consultants For Clinical Research Inc
🇺🇸Fairfield, Ohio, United States
Digestive Health Associates of Texas, P.A.dba DHAT Research Institute
🇺🇸Garland, Texas, United States
West Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Exemplar Research, Inc. - Elkins
🇺🇸Elkins, West Virginia, United States
West Virginia University Hospital
🇺🇸Morgantown, West Virginia, United States
University Hospital Centre Split
🇭🇷Split, Croatia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
University Multiprofile Hospital for Active Treatment Sveta Anna
🇧🇬Sofia, Bulgaria
PreventaMed s.r.o.
🇨🇿Olomouc, Olomoucký Kraj, Czechia
Uniklinik Köln
🇩🇪Köln, Nordrhein-Westfalen, Germany
University General Hospital of Patras
🇬🇷Patras, Greece
Gastroenterologische Facharztpraxis am Mexikoplatz
🇩🇪Berlin-Zehlendorf, Germany
Asklepios Westklinikum Hamburg Ggmbh
🇩🇪Hamburg, Germany
Azienda Ospedaliero Universitaria Di Modena Policlinico
🇮🇹Modena, Emilia-Romagna, Italy
Nazareth EMMS Hospital
🇮🇱Nazareth, Israel
Azienda Ospedale Università Padova
🇮🇹Padova, Veneto, Italy
Sapporo Medical University Hospital
🇯🇵Sapporo, Hokkaidô, Japan
Azienda Ospedaliera Ordine Mauriziano di Torino
🇮🇹Torino, Italy
Medical Corporation Aoyama Clinic
🇯🇵Kobe-shi, Hyôgo, Japan
Dokkyo Medical University Saitama Medical Center
🇯🇵Koshigaya, Saitama, Japan
Hakodate Koseiin Hakodate Goryoukaku Hospital
🇯🇵Hakodate, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Japan
Dokkyo Medical University Hospital
🇯🇵Shimotsuga-gun, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu-Shi, Japan
CHA Bundang Medical Center, CHA University
🇰🇷Seongnam, Gyeonggido, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
ETZ-Elisabeth
🇳🇱Tilburg, Noord-Brabant, Netherlands
NWZ, location Alkmaar
🇳🇱Alkmaar, Noord-Holland, Netherlands
Leids Universitair Medisch Centrum
🇳🇱Leiden, Zuid-Holland, Netherlands
Auckland City Hospital
🇳🇿Grafton, Auckland, New Zealand
Melita Medical
🇵🇱Wroclaw, Dolnoslaskie, Poland
Vitamed Galaj i Cichomski sp.j.
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow
🇵🇱Lódz, Lódzkie, Poland
Instytut Centrum Zdrowia Matki Polki
🇵🇱Lódz, Lódzkie, Poland
Centrum Medyczne Czestochowa - PRATIA - PPDS
🇵🇱Czestochowa, Poland
Clinical Research Center Spółka z Ograniczoną Odpowiedzialnością, Medic-R Spółka Komandytowa
🇵🇱Poznan, Poland
Centralny Szpital Kliniczny MSW
🇵🇱Warszawa, Poland
Dr.Carol Davila Emergency University Central Military Hospital
🇷🇴Bucharest, Romania
Affidea Romania SRL
🇷🇴Constanta, Romania
Dr. Goldis Gastroenterology Center SRL
🇷🇴Timisoara, Romania
St. Elizabeth Municipal Clinical Hospital
🇷🇺St. Petersburg, Sankt-Peterburg, Russian Federation
Moscow Clinical Scientific Center
🇷🇺Moscow, Russian Federation
Moscow Regional Research Clinical Institute Na Mfvladimirskiy
🇷🇺Moscow, Russian Federation
Nizhegorodskaya Regional Clinical Hospital n.a. Semashko
🇷🇺Nizhny Novgorod, Russian Federation
Rostov State Medical University
🇷🇺Rostov-on-Don, Russian Federation
Union Clinic, LLC
🇷🇺Saint Petersburg, Russian Federation
Medical University Reaviz
🇷🇺Samara, Russian Federation
Research Institute of Physiology and Basic Medicine
🇷🇺Novosibirsk, Russian Federation
Russian Medical Military Academy n.a. S.M. Kirov
🇷🇺Saint Petersburg, Russian Federation
Private Healthcare Institution Clinical Hospital RZD-Medicina of Samara city
🇷🇺Samara, Russian Federation
Medical Company Hepatolog, LLC
🇷🇺Samara, Russian Federation
SHI Regional Clinical Hospital
🇷🇺Saratov, Russian Federation
Smolensk Regional Clinical Hospital
🇷🇺Smoensk, Russian Federation
Stavropol State Medical University
🇷🇺Stavropol, Russian Federation
First St. Petersburg State Medical University n.a. I.P Pavlov
🇷🇺St. Petersburg, Russian Federation
Regional Consulting and Diagnostics Centre
🇷🇺Tyumen, Russian Federation
KM Management, spol. s r.o.
🇸🇰Nitra, Slovakia
CLINRESCO, ARWYP Medical Suites
🇿🇦Johannesburg, Gauteng, South Africa
Hospital Universitario de Fuenlabrada
🇪🇸Fuenlabrada, Madrid, Spain
Dr. J Breedt
🇿🇦Pretoria, Gauteng, South Africa
Dr JP Wright
🇿🇦Claremont, Western Cape, South Africa
C.H. Regional Reina Sofia - PPDS
🇪🇸Cordoba, Córdoba, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Madrid, Communidad Delaware, Spain
CHUVI - H.U. Alvaro Cunqueiro
🇪🇸Vigo, Pontevedra, Spain
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Universitario de La Princesa
🇪🇸Madrid, Spain
Hospital Universitario Juan Ramon Jimenez
🇪🇸Huelva, Spain
Hospital Universitario Virgen del Rocio - PPDS
🇪🇸Sevilla, Spain
Universität Zürich
🇨🇭Zürich, Zürich (de), Switzerland
Hospital Universitari i Politecnic La Fe de Valencia
🇪🇸Valencia, Spain
Istanbul Universitesi Cerrahpasa Tip Fakultesi
🇹🇷Istanbul, Turkey
Mersin University Medical Faculty
🇹🇷Mersin, Turkey
Regional Municipal Non-profit Enterprise "Chernivtsi Regional Clinical Hospital"
🇺🇦Chernivtsi, Chernivets'ka Oblast, Ukraine
ME Dnipropetrovsk Regional Clinical Hospital n.a. I.I Mechnykov Dnipropetrovsk Regional Council
🇺🇦Dnipro, Ukraine
Municipal Nonprofit Enterprise CCH #2 n.a. prof. O.O. Shalimov of Kharkiv City Council
🇺🇦Kharkiv, Kharkivs'ka Oblast, Ukraine
Clinic of SI National Institute of Therapy n.a. L.T. Mala of NAMS of Ukraine
🇺🇦Kharkiv, Ukraine
State Institution "Institute of Gastroenterology of National Academy of Medical Sciences of Ukraine"
🇺🇦Dnipro, Ukraine
Municipal Nonprofit Enterprise of Kharkiv Regional Council Regional Clinical Hospital
🇺🇦Kharkiv, Ukraine
MNPE of Kharkiv Regional Council Regional Clinical Specialised Dispensary of Radiation Protection
🇺🇦Kharkiv, Ukraine
Municipal Non-profit Enterprise Kherson City Clinical Hospital named after Ye.Ye. Karabelesh
🇺🇦Kherson, Ukraine
Kyiv City Clinical Hospital #18
🇺🇦Kyiv, Ukraine
Treatment and Diagnostic Center "Healthy and Happy" of LLC "Healthy and Happy"
🇺🇦Kyiv, Ukraine
Medical Center of LLC Medical Center Dopomoga-Plus
🇺🇦Kyiv, Ukraine
Medical Center of LLC Medical Clinic Blagomed
🇺🇦Kyiv, Ukraine
Medical Center OK!Clinic+LLC International Institute of Clinical Research
🇺🇦Kyiv, Ukraine
Municipal Non-profit Enterprise of Kyiv Regional Council Kyiv Regional Clinical Hospital
🇺🇦Kyiv, Ukraine
Municipal Non-profit Enterprise Odessa Regional Clinical Hospital of Odessa Regional Council
🇺🇦Odesa, Ukraine
MNPE Central City Clinical Hospital of Uzhhorod City Council
🇺🇦Uzhhorod, Ukraine
Medical Clinical Research Center of Medical Center LLC Health Clinic
🇺🇦Vinnytsia, Ukraine
MNE Lviv Territorial Med Ass-n Multidisciplinary Clinical Hospital for Intensive Care and Ambulance
🇺🇦Lviv, Ukraine
MNPE City Hospital No. 6 of Zaporizhzhia City Council
🇺🇦Zaporizhzhia, Ukraine
Whipps Cross University Hospital
🇬🇧London, London, City Of, United Kingdom
Communal Non-Commercial Enterprise Vinnytsia City Clinical Hospital 1
🇺🇦Vinnytsia, Ukraine
Aberdeen Royal Infirmary - PPDS
🇬🇧Aberdeen, United Kingdom
New Cross Hospital
🇬🇧Wolverhampton, United Kingdom
University Hospital Center Zagreb
🇭🇷Zagreb, Grad Zagreb, Croatia
General Hospital Virovitica
🇭🇷Virovitica, Croatia
General Hospital Zadar
🇭🇷Zadar, Croatia
Centrum Medyczne A-Z Clinic Mateusz Sidor, Piotr Puc-Lekarze Spolka Partnerska
🇵🇱Krakow, Poland
Centrum Medyczne Warszawa - PRATIA - PPDS
🇵🇱Warszawa, Poland
Opca bolnica Bjelovar
🇭🇷Bjelovar, Croatia
Twoja Przychodnia NCM
🇵🇱Nowa Sól, Poland
Szpital Specjalistyczny sw Lukasza - Oddzial Gastroenterologii
🇵🇱Konskie, Swietokrzyskie, Poland
Korczowski Bartosz, Gabinet Lekarski
🇵🇱Rzeszow, Poland
Centrum Zdrowia MDM
🇵🇱Warszawa, Poland
Szpital Zakonu Bonifratrow pw. Aniolow Strozow w Katowicach
🇵🇱Katowice, Slaskie, Poland
Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Centrum Opieki Zdrowotnej Orkan-Med Stec-Michalska Sp. J.
🇵🇱Ksawerow, Poland
Centrum Innowacyjnych Terapii
🇵🇱Piaseczno, Poland
Med Gastr Sp.z.o.o Sp.k
🇵🇱Lodz, Poland
H-T. Centrum Medyczne Endoterapia
🇵🇱Tychy, Poland
UZ Leuven- Gasthuisberg Campus
🇧🇪Leuven, Vlaams Brabant, Belgium
LLC Medical Center Family Medicine Clinic
🇺🇦Dnipro, Ukraine
Lviv Railway Clinical Hospital of branch Health Center of Joint Stock Co. Ukrainian Railway
🇺🇦Lviv, Ukraine
Municipal Non-profit Enterprise City Emergency Care Hospital of Zaporizhzhia Regional Council
🇺🇦Zaporizhzhia, Zaporiz'ka Oblast, Ukraine
Municipal Enterprise Kryvyi Rih City Clinical Hospital #2 of Kryvyi Rih City Council
🇺🇦Kryvyi Rih, Ukraine
Communal Non-profit Enterprise of Kyiv Regional Council Kyiv Regional Hospital
🇺🇦Kyiv, Ukraine
Communal Nonprofit Enterprise Vinnytsia Regional Clinical Hospital named after N.I. Pirogov VRC
🇺🇦Vinnytsia, Ukraine
Omega Research Consultants LLC - Clinedge - PPDS
🇺🇸Orlando, Florida, United States
DelRicht Clinical Research, LLC - ClinEdge - PPDS
🇺🇸New Orleans, Louisiana, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
Clinical Trials of SWLA LLC
🇺🇸Lake Charles, Louisiana, United States