PTSD, AUD, and Interpersonal Conflict: Within-person Associations

Not Applicable

Recruiting

• Conditions: Stress Disorders, Post-Traumatic; Alcoholism

• Registration Number: NCT04552782
• Lead Sponsor: University of South Dakota

Brief Summary

The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD symptoms, and PTSD symptoms in the real world.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-09-10
• Study First Submitted QC: 2020-09-10
• Study First Posted: 2020-09-17
• Study Start: 2020-12-04
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-08
• Last Update Posted: 2023-05-09
• Primary Completion: 2025-04-30
• Study Completion: 2025-04-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• OIF/OEF/OND veterans
• At risk for PTSD (i.e., PCL-5 ≥33) and/or AUD (i.e., AUDIT ≥ 7 (women) ≥ 8 (men))

Exclusion Criteria

• Psychosis or severe Alcohol Use Disorder that contraindicates participation (based on interview)
• Active suicidal or homicidal ideation that contraindicates participation (based on interview)
• [exclusion criteria removed 6/2022] - Severe risk for sleep apnea (a positive score in three categories of the Berlin Questionnaire), or reported treatment for sleep apnea

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Rate of PTSD Symptoms	2 years	These are experience sampling items derived from the PTSD Checklist from DSM-5 (PCL-5).
Rate of Alcohol Use Disorder Symptoms	2 years	These are experience sampling items derived from Diagnostic and Statistical Manual of Mental Disorders (DSM-5).

Trial Locations

Locations (3)

Bay Pines VA Health Care System; 🇺🇸 Bay Pines, Florida, United States

Sioux Falls VA Health Care System; 🇺🇸 Sioux Falls, South Dakota, United States

The University of South Dakota; 🇺🇸 Vermillion, South Dakota, United States