PTSD, AUD, and Interpersonal Conflict: Within-person Associations
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 250
- 试验地点
- 6
- 主要终点
- Rate of PTSD Symptoms
研究概览
简要总结
The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD symptoms, and PTSD symptoms in the real world.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •OIF/OEF/OND veterans
- •At risk for PTSD (i.e., PCL-5 ≥33) and/or AUD (i.e., AUDIT ≥ 7 (women) ≥ 8 (men))
排除标准
- •Psychosis or severe Alcohol Use Disorder that contraindicates participation (based on interview)
- •Active suicidal or homicidal ideation that contraindicates participation (based on interview)
- •[exclusion criteria removed 6/2022] - Severe risk for sleep apnea (a positive score in three categories of the Berlin Questionnaire), or reported treatment for sleep apnea
结局指标
主要结局
Rate of PTSD Symptoms
时间窗: 2 years
These are experience sampling items derived from the PTSD Checklist from DSM-5 (PCL-5).
Rate of Alcohol Use Disorder Symptoms
时间窗: 2 years
These are experience sampling items derived from Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
次要结局
未报告次要终点