eurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing.
- Conditions
- antisocial behaviourbehavioural problems10034726
- Registration Number
- NL-OMON44782
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 180
- Age: 9-18 years old
- normal or corrected to normal vision and hearing
- good level of Dutch reading and listening
- Diagnostic criteria for CASES:
current diagnosis of Conduct Disorder (CD) OR diagnosis of CD in the past, while currently 'only' two symptoms of Oppositional Defiant Disorder (ODD) are present in combination with one CD symptom.
OR:
- 9-12 year olds: Diagnosis of ODD + (at least) one symptom of CD
- 13-18 year olds: Diagnosis of ODD + (at least) two symptoms of CD;- Diagnostic criteria for controls: no current psychiatric disorder and no history of ADHD, ODD, CD
- formal clinical diagnosis of an autism spectrum disorder or a neurodevelopmental syndrome
- IQ < 70
- Inability to speak or understand Dutch
- being pregnant or having recently given birth (within the last 6 months)
- severe head injury with prolonged loss of consciousness (> 1 hour) or confirmed traumatic brain injury
- severe epilepsy
- exclusion criterion for the control group: any Axis I disorder, or diagnosis of CD, ODD, ADHD in the past
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>• Autonomic Nervous System activity: heart rate, heart rate variability,<br /><br>respiratory sinus arrhythmia, pre-ejection period, and skin conductance level<br /><br>in rest and during reactivity to emotionally arousing stimuli<br /><br>• Neuroendocrinology: basal levels of cortisol, testosterone,<br /><br>dehydroepiandrosterone sulfate (DHEA-S), alpha-amylase, progesterone,<br /><br>estradiol, oxytocin, and Vasopressin (AVP). And reactivity to a social stressor<br /><br>of cortisol and testosterone. </p><br>
- Secondary Outcome Measures
Name Time Method <p>• Psychiatric disorders<br /><br>• Psychopathic traits<br /><br>• Intelligence<br /><br>• Reactive and proactive aggression<br /><br>• Parenting behavior<br /><br>• Emotion Regulation<br /><br>• Empathy<br /><br>• Pubertal development<br /><br>• Callous-Unemotional traits<br /><br>• Socio-demographic factors<br /><br>• Medication and drug use<br /><br>• Brain structure and functioning </p><br>
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