Clinical Evaluation of Fenestration Decompression Combined With Secondary Curettage for Ameloblastoma of the Jaw: Retrospective Radiographic Analysis

Completed

• Conditions: the Recurrence of the Tumor; Cystic Cavity Area Reduction Efficiency
• Interventions: Procedure: fenestration decompression combined with secondary curettage

• Registration Number: NCT04987515
• Lead Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Brief Summary

Objectives: To investigate the outcomes of fenestration decompression combined with secondary curettage (FDSC) in the surgical treatment of jaw ameloblastoma.

Methods: Medical records of patients diagnosed as multicystic ameloblastoma (MA) or unicystic ameloblastoma (UA) by routine pathology were collected from January 2010 to December 2017 in Ninth People's Hospital, Shanghai JiaoTong University Medical College. Patients were divided into two groups based on the management regimen: FDSC group, and local curettage (LC) group. Patients were followed up for 3-8 years, using panoramic radiography to measure the change of the area of the cystic cavity involved in ameloblastoma and the recurrence or malignant transformation of the tumor in both groups. A total of 233 eligible patients were selected for provisional screening, including 145 patients with MA, and 88 patients with UA.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2017-12-31
• Study Completion: 2021-07-01
• Study First Submitted: 2021-07-30
• Study First Submitted QC: 2021-07-30
• Study First Posted: 2021-08-03
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-14
• Last Update Posted: 2021-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 233

Inclusion Criteria

-Medical records of patients who were diagnosed with multicystic ameloblastoma (MA) or unicystic ameloblastoma (UA) by routine pathology were collected from January 2010 to December 2017 in Ninth People's Hospital of Shanghai JiaoTong University Medical College.

Exclusion Criteria

• followed up less than 3 years
• For FDSC group, fenestration decompression failed
• recurrent ameloblastoma
• received other type of surgery;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Fenestration decompression combined with secondary curettage (FDSC)	fenestration decompression combined with secondary curettage	Design of the opening window reasonably；Making cyst plug；secondary curettage

Primary Outcome Measures

Name	Time	Method
Cystic cavity area reduction efficiency	3 years after surgery	(good effect case number + moderate effect case number)/total case number

Secondary Outcome Measures

Name	Time	Method
Tumor recurrence rate	3 years after surgery	the recurrence case number/total case number