Feasibility of skeletal muscle biopsy and near-infrared spectrometry in post-ICU patients: the Powerhouse feasibility study

• Conditions: Post-Intensive Care Syndroom; Post-Intensive Care Syndrome; 10047635; Recovery issues after Intensive Care admission

• Registration Number: NL-OMON56670
• Lead Sponsor: Ziekenhuisvoorzieningen Gelderse Vallei

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 5

Inclusion Criteria

1) >=18 years of age 2) Medical research council (MRC) sum score of at least 24
and less than 48 3) Serum haemoglobin of at least 5.0 mmol/L 4) BMI < 30 kg/m2
5) Admitted to an intensive care unit for at least 72 hours 6) exptected to be
discharged from the ICU within 48 hours 7) Written informed consent

Exclusion Criteria

1) Known mitochondrial disease
2) Pre-existent muscle disease
3) Diabetes Mellitus
4) Life expectancy less than 6 months
5) Visibly high melanin content in the skin
6) Subcutaneous fat layer > 3cm covering the GA muscle (measured by
ultrasound)
7) Coagulopathy (i.e. platelet count; < 50 x10 9 cells/ml, INR > 2.0 or recent
treatment with therapeutic dosage of low molecular weight heparin)
8) Recent lower extremity surgery
9) Delirium (defined as a delirium observation screening scale (DOS) of at
least three)
10) Deemed incompetent to provide well-considered informed consent by the
treating physician

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified