comparison of time taken to reverse the action of neuromuscular relaxant used during general anesthesia by sugammadex a novel drug with neostigmine-glycopyrrolate which is time tested drug
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/07/055309
- Lead Sponsor
- P. D. Hinduja National Hospital and Medical Research Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. All elective surgeries under general anesthesia, with anticipated surgical time of 2 to 3 hours.
2. ASA Grade I and II patients.
Exclusion Criteria
1.Patient refusal.
2.Renal dysfunction.
3.Hepatic dysfunction.
4.Patients with expected difficult intubation.
5.Those receiving medication like amikacin, bacitracin, phenytoin, aminoglycosides, polymyin B which interact with rocuronium.
6.Allergy to muscle relaxants or other drug used during anesthesia.
7.Female patients who are pregnant or breast feeding.
8.Cognitive impairment.
9.Patient with psychiatric disease.
10.Incomplete or unreliable history/clinical data.
11.Patients on beta blockade.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To measure the efficacy of sugammadex compared to neostigmine by comparing the time of extubation after administering the reversal drugs in rocuronium induced neuromuscular blockage under sevoflurane. <br/ ><br>Timepoint: 1using neuromuscular Monitoring measuring the time taken to achieve tof count of 0.7,0.8,0.9 and time of extubation
- Secondary Outcome Measures
Name Time Method To record the hemodynamic changes, if any, with the use of either sugammadex or neostigmine glycopyrrolate combination <br/ ><br>side effects profile of sugammadexTimepoint: 1. To measure hemodynamic stability measuring NIBP,pulse,spo2 & respiratory rate at before extubation, after extubation, 1,2,3,4,5,10,15,30,45,and 60min after extubation <br/ ><br>2.any adverse event in post operative period