Comparing hormone profile and outcomes of ovulation triggering with GnRH and HGC in IVF
Phase 2
- Conditions
- Female infertility.Female infertility
- Registration Number
- IRCT2015060222541N1
- Lead Sponsor
- Vice Chancellor of Research, Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 232
Inclusion Criteria
All patients who are candidate for IVF/ICSI( Male factor infertility, unexplained infertility, tubal factor infertility), Age below 39 years old, BMI: 18-29, Regular menstrual cycles.Agreement of patient to enrol the research
Exclusion criteria: Ovulatory factor infertility, Endometriosis, Uterine anomalies, Age above 39 years old, Non-agreement of patient to enrol the research
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber and Quality of oocytes retrieved in each IVF cycle. Timepoint: on day of ovum pick up. Method of measurement: measuring number and quality of oocytes on the day of pick up by pathologist in lab under microscope and scoring.;Progesterone level. Timepoint: on the day of injection HCG or GnRH agonist(Final Triggering) and rechecked 7 and 14 days after that. Method of measurement: Serum Level, Lab test.;Number and Quality of embryos transferred in IVF cycle. Timepoint: on day of embryo transfer. Method of measurement: measuring number and quality of embryos by pathologist in lab under microscope and grading.;Comparing FSH, LH, Estradiol and HCG in both groups. Timepoint: on days 2 and 6 of menstrual cycle, final oocyte triggering, oocyte retrieval, 7 and 14 days after that oocyte retrieved. Method of measurement: Serum Level, Lab test.
- Secondary Outcome Measures
Name Time Method Rate of ovarian hyperstimulation syndrome (OHSS). Timepoint: From day of HCG or GnRH agonist injection up to 2 weeks later. Method of measurement: Clinical management of symptoms, Sonography.;Clinical Pregnancy. Timepoint: 16 days after triggering if menstruation was absent. Method of measurement: Serum BHCG and TVS.