Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Trimethylamine-N-oxidec(TMAO) blood concentration
研究概览
简要总结
The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.
The hypothesis is that in patients with recent myocardial infarction, TMAO concentration in blood is higher than in patients undergoing scheduled coronarography.
详细描述
To the study will be included volunteers - patients with stable angina (SA), who were scheduled for conventional coronary angiography, and patients with acute coronary syndrome (ACS) who were admitted to the hospital with chest pain and undergoing coronography surgery. Blood samples will be taken from volunteers once - before the coronography surgery by qualified medical personnel.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosed stable angina (SA) or acute coronary syndrome (ACS) and planned coronography
排除标准
- •unconscious patient
结局指标
主要结局
Trimethylamine-N-oxidec(TMAO) blood concentration
时间窗: Immediately before coronography.
TMAO concentration determined by the ultra-performance liquid-chromatography tandem mass spektrometry (UPLC-MS/MS).
次要结局
未报告次要终点
研究者
Robert Olek
Associate Professor
Gdansk University of Physical Education and Sport