The effect of two dosing regimens cefotaxime on the presence of potential pathogenic micro-organisms in airways.
Completed
- Conditions
- in potential harmful bacteriapotential pathogenic microorganisms10024970
- Registration Number
- NL-OMON33091
- Lead Sponsor
- Medisch Centrum Haaglanden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 104
Inclusion Criteria
All patients expected to be intubated for more than 24 hours.
All non-intubated patiënts who are expected to receive enteral tube feeding for more than 48 hours.
Exclusion Criteria
Pneumonia at admission on the ICU
Expected death within 48 hours
Immunocompromised patients
Pregnancy
Antibiotic therapy within the last 48 hours before admission at the ICU
No informed consent within 24 hours after admission at the ICU
Cephalosporin allergy
ICU admission in the previous 30 days
Age below 18 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameter is airway colonisation by potential pathogenic<br /><br>microorganisms after four days of selective decontamination of the digestive<br /><br>tract.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters are length of stay on the ICU, length of stay in the<br /><br>hospital, ICU mortality, hospital mortality, duration of mechanical ventilation<br /><br>and pneumonia during ICU admission following the criteria of the Centers for<br /><br>Disease Control.</p><br>