ASIC channels and migraine disorders - Proof of concept study on the efficacy of Amiloride in prophylaxis of Migraine with Aura - APAM study - APAM

CHU de Nice0 个研究点目标入组 40 人开始时间: 2018年11月6日最近更新: 2024年4月22日

适应症

试验速览

暂无简介。

•- Subjects aged 18 to 80 years
•- Male or female
•- Diagnosis of migraine with aura code 1.2.1 according to ICHD-3 including codes 1.2.1.1.1 and 1.2.1.2
•- At least 1 crisis with aura per month in the 3 months prior to inclusion
•- No prophylactic migraine background treatment for at least 1 month before inclusion
•- For women of childbearing age, use of a reliable contraceptive method at least 3 months before and 1 month after the study
•- Signing of written informed consent
•- Patient affiliated to social security
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 30
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 10

•- Existence of contraindications to taking amiloride:
•- Known hypersensitivity to the molecule
•- Hyperkalemia
•- Use of another hyperkalemic diuretic or potassium salts
•- Renal insufficiency (clearance < 60 ml/min)
•- Severe hepatocellular insufficiency
•- Patient, who from the investigator's point of view would not be compliant with the study procedure
•- Pregnant or breastfeeding patient
•- Patient under guardianship, protected by law

发起方