Comparison of effect of airway nebulization with lignocaine and dexmedetomidine on hemodynamic stress response to laryngoscopy and intubation in patients undergoing elective surgery under general endotracheal anaesthesia – A prospective randomized double blind study
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- To study and compare the hemodynamic stress response Heart rate(HR), systolic blood pressure(SBP), diastolic blood pressure (DBP)and mean arterial pressure(MAP) to laryngoscopy and intubation between 4% lignocaine group and Dexmedetomidine group
研究概览
简要总结
Dexmedetomidine, a selective alpha2-adrenoceptor agonist, is short-acting and has sedative, hypnotic, anxiolytic, analgesic, anti-sialagogue, sympatholytic properties and promotes cardiac, respiratory and neurological stability
Lignocaine is an amino- ethylamide and prototype of amide local anesthetic group. It is the most widely used local anesthetic. Showed that its intravenous use blunted pressure response to intubation. Lignocaine is also used in various routes of administration. Lignocaine is also given in nebulization route. Both these drugs are known to decrease the hemodynamic stress response to intubation.
The present study is undertaken to study and compare the efficacy lignocaine 4% (3mg/kg) and dexmedetomidine (1mcg/kg) nebulization to attenuate the hemodynamic stress response in patients undergoing elective surgeries under general anesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 68.00 Year(s)（—）
- 性别
- All
入选标准
- •patient aged 18 to 65 years American society of anaesthesiologist status I and II patient scheduled to undergo surgery of less than 3 hours who require endotracheal intubation.
排除标准
- •1.Patients not willing to give consent.
- •2.BMI greater than 30 kg/m2 3.Pregnant and lactating women 4.Patients with known allergy to study drugs.
- •5.Patients with uncontrolled systemic diseases 6.Anticipated difficult intubation 7.Laryngoscopy more than 20 seconds and more than 1 attempt at intubation are excluded retrospectively 8.Patients having a history of preoperative sore throat or recent upper respiratory tract infection.
结局指标
主要结局
To study and compare the hemodynamic stress response Heart rate(HR), systolic blood pressure(SBP), diastolic blood pressure (DBP)and mean arterial pressure(MAP) to laryngoscopy and intubation between 4% lignocaine group and Dexmedetomidine group
时间窗: at baseline (T0), after induction(T1), immediately after intubation(T2), at 1 min(T3), 2 min(T4), 3min(T5) and 5min(T6) after intubation.
次要结局
- 1.To study the incidence of post operative sedation score using Ramsay sedation score (RSS).(2.To study the incidence of post operative sore throat or cough at 0, 6, 12, 24 hrs after tracheal extubation)
研究者
Dr Jaisakthivel K S
Sri venkateswara institute of medical sciences