Comparison of incidence of hypotension in height adjusted dose vs fixed dose of bupivacaine in spinal anesthesia in cesarean section: A randomised controlled trial
Trial Snapshot
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Incidence of hypotension in height adjusted dose of 0.5% heavy bupivacaine (0.06mg/cm) in cesarean section under spinal anaesthesia compared to fixed dose 2ml(10mg) 0.5% heavy bupivacaine in cesarean section under spinal anaesthesia in control group
Study Overview
Brief Summary
The aim of this study is to compare incidence of hypotension in one group receiving height adjusted dose of heavy bupivacaine 0.5%(0.06mg/cm) with other group receiving fixed dose of heavy bupivacaine 0.5% in parturients for cesarean section under spinal anaesthesia.
Following is also compared in each group:
Incidence of nausea and vomiting
Intraoperative fluid requirement
Cumulative dose of vasopressor used
Extent of surgical anaesthesia
Other complications if any (bradycardia,dyspnea)
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 50.00 Year(s) (—)
- Sex
- Female
Inclusion Criteria
- •Age more than 18 yrs ASA1,2 Elective cesarean section Singleton pregnancy more than 37weeks Uncomplicated pregnancy.
Exclusion Criteria
- •Presenting with any systemic illness Emergent surgery and labouring parturients Multiple or twin pregnancy.
Outcomes
Primary Outcomes
Incidence of hypotension in height adjusted dose of 0.5% heavy bupivacaine (0.06mg/cm) in cesarean section under spinal anaesthesia compared to fixed dose 2ml(10mg) 0.5% heavy bupivacaine in cesarean section under spinal anaesthesia in control group
Time Frame: Blood pressure reading will be monitored once before spinal anaesthesia then after spinal anaesthesia every 1 min for 10 mins, every 5mins till 30 mins then every 10 mins till end of surgery.
Secondary Outcomes
- Incidence of nausea and vomiting in each group(After spinal anaesthesia till end of surgery)
- Intraoperative fluid requirement(After spinal anaesthesia till end of surgery)
- Cumulative dose of vasopressor(ephedrine) required(After spinal anaesthesia till the end of surgery)
- Extent of surgical anaesthesia in each group(Time to achieve T6 level of sensory block and highest level of sensory block will be noted after administration of drug.)
- Other complications if any(After intrathecal drug administration in each group)
Investigators
Pratima
Dr SN Medical college, Jodhpur