nravelling the measles paradox: a disease associated with both immune suppression and immune activatio

• Conditions: airborne disease; measles virus; 10047438

• Registration Number: NL-OMON56923
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

Cohort A (18-25 years)
- No known history of measles or vaccination
- Decided to take MMR vaccination before the upcoming measles outbreak

Cohort B (18-25 years)
- No known history of measles or vaccination (seronegative confirmed)
- Contracted measles during the upcoming outbreak

Cohort C (18-25 years)
- No known history of measles or vaccination (seronegative confirmed)

Cohort D (18-25 years)
- Experienced measles during the 2013 outbreak

Cohort E (18-25 years)
- Received second dose of measles vaccines ±10 years ago

Exclusion Criteria

1. Diagnosed chronic disease
2. Immune suppression (due to medication or underlying disease)
3. Additionally for subjects recruited to Cohort A:
-pregnant women or women planning to get pregnant in less than one
month after the start of the
study. This is a precaution; the MMR vaccine is not recommended for
pregnant women.
-People who have had a severe allergic reaction (e.g., anaphylaxis)
after a previous vaccination.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the immune repertoire before and after measles.</p><br>