Strength Training Adaptations, Age and Genes

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Behavioral: Strength training

• Registration Number: NCT02589990
• Lead Sponsor: University of South-Eastern Norway

Brief Summary

The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.

Detailed Description

Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.

Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.

Hypothesis: Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.

Study Timeline

• Study First Submitted: 2015-09-24
• Study First Submitted QC: 2015-10-27
• Study First Posted: 2015-10-28
• Study Start: 2016-01
• Primary Completion: 2018-08
• Status Verified: 2018-09
• Study Completion: 2018-09-03
• Last Update Submitted: 2018-09-27
• Last Update Posted: 2018-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• Healthy adults 20 to 90 years old

Exclusion Criteria

• Contraindications to maximum strength training and testing

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Strength training	Strength training	Strength training, 4 rep of 4RM x 4 sets in leg press.

Primary Outcome Measures

Name	Time	Method
Maximal muscle strength measured by 1 RM leg press in leg press machine	8 weeks

Secondary Outcome Measures

Name	Time	Method
Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen	8 weeks
rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway)	8 weeks
agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway)	8 weeks

Trial Locations

Locations (2)

Norwegian University of Science and Technology; 🇳🇴 Trondheim, Norway

Telemark University College; 🇳🇴 Bø, Telemark, Norway