Interaction of Otolith Stimulation and Carotid Baroreflex in Humans
试验速览
- 阶段
- 不适用
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Arterial flow in Common Carotid Artery (EchoDoppler)
研究概览
简要总结
It is well documented that a few days stay in space induces a change in the vestibular-ocular reflex reflecting a reinterpretation of sensory inputs following the disappearance of gravity. If the change of eye reflexes actually the result of a reinterpretation of sensory input, the investigators should also expect to see an alteration of the vestibular-cardiovascular reflexes. The modification of these reflexes may modulate the carotid baroreflex and thus participate in the post-flight cardiovascular deconditioning.
The first objective of this project is to study the carotid baroreflex under different supine (dorsal, ventral and lateral) inducing different otolith stimulation in normal-gravity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers, male and / or female aged 18-30 years
- •subject affiliated to a social security scheme, agreeing to participate in the study and who provided informed consent.
排除标准
- •who participated in a clinical trial within less than the period of exclusion from this project
- •with a past or present history of heart disease, vascular, neurological, respiratory, rheumatological, metabolic or otologic.
- •pregnant women (dosage beta HCG)
- •having taken any medication heart, vascular, neurological, respiratory, rheumatological, metabolic or might interfere on vestibular test results during the two years preceding the experiment.
- •smoking or smoking more than 5 cigarettes / day, 1 cigarette / day or 1 pipe / day
研究组 & 干预措施
Carotid Baroreflex measurements
干预措施: Stimulation of the carotid baroreceptors with a pressure system (Procedure)
结局指标
主要结局
Arterial flow in Common Carotid Artery (EchoDoppler)
时间窗: baseline
Measurements of Common Carotid Artery Blood Flow in Cm/s
Arterial flow in Internal Carotid Artery (EchoDoppler)
时间窗: Baseline
Measurements of Internal Carotid Artery Blood Flow in Cm/s
Arterial flow in Vertebral Artery (EchoDoppler)
时间窗: Baseline
Measurements of Vertebral Artery Blood Flow in Cm/s
Arterial flow in External Carotid Artery (EchoDoppler)
时间窗: Baseline
Measurements of External Carotid Artery Blood Flow in Cm/s
次要结局
未报告次要终点