Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.

• Conditions: Pregnancy

• Registration Number: NCT02192177
• Lead Sponsor: Zekai Tahir Burak Women's Health Research and Education Hospital

Brief Summary

Intrahepatic cholestasis of pregnancy is a disease specific to pregnancy period; especially late second and third trimester. We aimed to investigate the role of apoptosis in etiopathogenesis of obstetric cholestasis.

Detailed Description

M30 (caspases cleaved Cytokeratin-18 (CK-18) fragment) is a specific apoptosis marker. We aimed to use it to evaluate the apoptotic process.

Study Timeline

• Study Start: 2013-09
• Status Verified: 2014-07
• Study First Submitted: 2014-07-12
• Study First Submitted QC: 2014-07-14
• Last Update Submitted: 2014-07-14
• Study First Posted: 2014-07-16
• Last Update Posted: 2014-07-16
• Primary Completion: 2014-08
• Study Completion: 2014-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• Late second or third trimester of pregnancy.

Exclusion Criteria

• Foreknown systemic diseases, multiple pregnancy, smoking cigarettes.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
M30 value as Unit per Liter.	Four months.

Secondary Outcome Measures

Name	Time	Method
Percentage of delivery with cesarean section.	Four months.

Trial Locations

Locations (1)

Zekai Tahir Burak Maternity Teaching Hospital; 🇹🇷 Ankara, Turkey