Influence of Arterial Tone Changes on Cardiac Output Measurement by Pressure Recording Analytical Method
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Changes of cardiac output after variation of noradrenaline dose: ECO versus PRAM
Study Overview
Brief Summary
This study evaluates the role of arterial tone in the accuracy of cardiac output (CO) measurement by Pressure Recording Analytical Method (PRAM). Patients receiving noradrenaline who need for clinical reason to change the noradrenaline dose will be enrolled. We use echocardiography as reference method of CO measurement.
Detailed Description
Pressure Recording Analytical Method (PRAM) is an arterial pulse contour analysis method for CO measurement. As it is an uncalibrated method, one possible reason for its inaccuracy is rapid changes in arterial tone.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •invasive blood pressure monitoring on site
- •need to start or change the dose of noradrenaline infusion for clinical reason
Exclusion Criteria
- •arrhythmia
- •severe valvular insufficiency
- •pregnancy
- •low quality arterial signal
Outcomes
Primary Outcomes
Changes of cardiac output after variation of noradrenaline dose: ECO versus PRAM
Time Frame: Before and 30 minutes after noradrenaline dose variation
Agreement between echocardiography and PRAM in CO measurement during arterial tone changes induced by different dose of noradrenaline
Secondary Outcomes
No secondary outcomes reported
Investigators
Abele Donati, MD
Professor
Università Politecnica delle Marche