The Mechanistic Effect of Ketones on Cerebral Blood Flow and Cerebrovascular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Resting cerebral blood flow (CBF)
研究概览
简要总结
Oral supplements containing exogenous ketones have recently become available and represent a novel tool for increasing plasma ketone bodies without the need for dietary restriction. Early evidence suggests that oral ketone supplements may enhance cerebral blood flow (CBF). However, a higher dose of a ketone monoester has been shown to slightly lower blood pH and reduce end-tidal CO2 (PetCO2) due to compensatory hyperventilation, which is accompanied by parallel reductions in CBF. Whether reductions in PetCO2 causes reductions in CBF is currently unknown.
The purpose of this study is to investigate the effect of manipulating PetCO2 at normocapnia (PetCO2 maintained at baseline) or poikilocapnia (no PetCO2 targeting; breathing room air), following the ingestion of a dose of a ketone monoester on CBF and cerebrovascular reactivity to CO2 in young adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Having a normal blood pressure (≤125/≤85 mmHg)
- •Between the ages of 18 and 35
排除标准
- •Individuals who are obese (body mass index > 30 kg/m^2)
- •Individuals who smoke
- •Individuals with respiratory illnesses
- •A history of type 2 diabetes, hypoglycemia, or cardiovascular diseases (i.e. heart attack, stroke)
- •Individuals currently following a ketogenic diet or taking ketone supplements
- •Individuals with a history of concussion(s) with persistent symptoms
- •Individuals participating in elite-level physical training (i.e. varsity athletics)
结局指标
主要结局
Resting cerebral blood flow (CBF)
时间窗: 90-minutes
Measured via duplex ultrasound of the internal carotid artery and vertebral artery
次要结局
- Plasma beta-hydroxybutyrate area under the curve(90-minutes)
- Middle Cerebral Artery Blood Velocity(90-minutes)
- Cerebrovascular Reactivity of the Internal Carotid and Middle Cerebral Artery as assessed by Duplex Ultrasound and Transcranial Doppler Ultrasound, respectively.(90-minutes)
- Blood pH(90-minutes)
- End-tidal CO2(90-minutes)
- Mean arterial pressure (MAP)(90-minutes)
研究者
Jeremy Walsh
Assistant Professor
McMaster University