NCT00624949Unknown不适用
Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 102
- 主要终点
- Aortic diameter at 3 well-defined levels measured by MRI and ECHO
研究概览
简要总结
An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Turner syndrome
- •Age 18-70 years
排除标准
- •Extreme adipositas
- •Contraindications to a MRI scan
- •Malignant disease
结局指标
主要结局
Aortic diameter at 3 well-defined levels measured by MRI and ECHO
时间窗: 2-yearly for 6 years
次要结局
- 24hour ambulatory blood pressure(24h 2-yearly for 6 years)
研究者
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