Comparing recovery profile of two independent inhalational anaesthetic agents Desflurane and Sevoflurane in patients undergoing Transnasal Trans-sphenoidal surgery for pituitary tumors with the help of Bispectral index which is a tool to monitor and analyze the depth of anaesthesia
Not Applicable
- Conditions
- Health Condition 1: D352- Benign neoplasm of pituitary gland
- Registration Number
- CTRI/2024/03/064312
- Lead Sponsor
- ABVIMS and Dr.RML hospital, New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Adult patients:18-65 years of age
2. ASA Grade I and Grade II
3. Patient posted for elective Transnasal trans-sphenoidal surgery for pituitary tumors
Exclusion Criteria
1. History of previous pituitary surgery
2. Patients with GCS less than 15
3. Patients with psychiatric disorders with history of any drug abuse
4. Poorly controlled Hypertension/Diabetes Mellitus
5. Ischemic heart disease
6. Pituitary apoplexy
7. History of allergy to any of the planned anaesthetic medications for the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Recovery profile by using BIS values <br/ ><br>Timepoint: 1.Time taken from the discontinuation of maintenance anaesthetic agent to the BIS value to reach 70 for clinical recovery (mins) <br/ ><br>2.Time taken from the administration of reversal to the BIS value to reach 85-90 for Extubation (mins) <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Hemodynamic parameters (Heart rate in beats/min, MAP in mmHg) <br/ ><br> <br/ ><br>2.The total top up increments of rescue anaesthetic agent-propofol (1mg/kg) during maintenance when the BIS value exceeds more than 60. <br/ ><br>Timepoint: <br/ ><br> <br/ ><br>Heart rate and Mean arterial pressure <br/ ><br>•At baseline <br/ ><br>•At pre-intubation <br/ ><br>•At post-intubation <br/ ><br>•At BIS value of 55 <br/ ><br>•At BIS value of 70 (Recovery) <br/ ><br>•At BIS value of 85-90 (Extubation) <br/ ><br>