The Microcirculation in Acute Myocardial Infarction (Micro-AMI)

Completed

• Conditions: STEMI
• Interventions: Procedure: Index of microvascular resistance; Other: Cardiac magnetic resonance; Other: Blood markers

• Registration Number: NCT01552564
• Lead Sponsor: University of Bristol

Brief Summary

This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2012-03-09
• Study First Submitted QC: 2012-03-12
• Study First Posted: 2012-03-13
• Primary Completion: 2014-01
• Status Verified: 2014-10
• Last Update Submitted: 2014-10-27
• Last Update Posted: 2014-10-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• >18 years old
• Cardiac symptoms of > 20 mins chest pain or equivalent.
• ECG criteria consistent with STEMI (STEMI)
• Proceeding with percutaneous angioplasty
• Assent/ consent to the study

Exclusion Criteria

• Known allergy to adenosine or gadolinium
• Chronic atrial fibrillation
• Renal impairment with eGFR <30
• Contraindication to angiography
• Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner)
• Cardiogenic shock
• Patients with special communication needs or altered consciousness.
• Patients who do not give assent/consent to the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
STEMI patients	Cardiac magnetic resonance	Consecutive patients presenting through the PPCI service
STEMI patients	Index of microvascular resistance	Consecutive patients presenting through the PPCI service
STEMI patients	Blood markers	Consecutive patients presenting through the PPCI service

Primary Outcome Measures

Name	Time	Method
Microvascular obstruction	DAy 2-4	Microvascular obstruction as a percentage of the left ventricle at 2-4 days.

Trial Locations

Locations (1)

Bristol Heart Institute; 🇬🇧 Bristol, United Kingdom