The Microcirculation in Acute Myocardial Infarction (Micro-AMI)
Completed
- Conditions
- STEMI
- Interventions
- Procedure: Index of microvascular resistanceOther: Cardiac magnetic resonanceOther: Blood markers
- Registration Number
- NCT01552564
- Lead Sponsor
- University of Bristol
- Brief Summary
This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- >18 years old
- Cardiac symptoms of > 20 mins chest pain or equivalent.
- ECG criteria consistent with STEMI (STEMI)
- Proceeding with percutaneous angioplasty
- Assent/ consent to the study
Exclusion Criteria
- Known allergy to adenosine or gadolinium
- Chronic atrial fibrillation
- Renal impairment with eGFR <30
- Contraindication to angiography
- Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner)
- Cardiogenic shock
- Patients with special communication needs or altered consciousness.
- Patients who do not give assent/consent to the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description STEMI patients Cardiac magnetic resonance Consecutive patients presenting through the PPCI service STEMI patients Index of microvascular resistance Consecutive patients presenting through the PPCI service STEMI patients Blood markers Consecutive patients presenting through the PPCI service
- Primary Outcome Measures
Name Time Method Microvascular obstruction DAy 2-4 Microvascular obstruction as a percentage of the left ventricle at 2-4 days.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Bristol Heart Institute
🇬🇧Bristol, United Kingdom