Resistant Bacterial Infections in the Early Post LDLT Period
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 主要终点
- Determine the types of early bacterial infections following LDLT, recurrent and resistant infections all were confirmed by cultures.
研究概览
简要总结
The purpose of this work was to study the incidence, types, risk factors and causative organisms of bacterial infections in HCV Egyptian patients following Liver Transplantation. Moreover, to identify the emerging resistant strains and their proper antimicrobial therapy
详细描述
This prospective descriptive study has been done at Tropical Medicine department in the period between January 2014 to November 2015.
After the approval of the scientific and ethical committee of Ain Shams University Hospital, Patients with HCV positive end stage liver disease (ESLD) eligible for liver transplantation Ain Shams Center for Organ Transplant (ASCOT); Ain Shams University, (fulfilling the inclusion criteria) were included in the current study. Forty five patients were recruited and each one was followed-up during a period of 3 months following transplantation.
Included patients were divided into 2 groups:
Group 1 included patients who had a postoperative single episode of infection. Group 2 included those patients who had more than 1 episode of postoperative bacterial infection whom were further evaluated for the presence of emerging strains and/or antibiotic resistance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Egyptian nationality.
- •Accepting participation in the current study and signing a written consent form
- •Age between 18-60 Years, including males and females.
排除标准
- •Patients who refused to be enrolled in the study.
- •Patients with other etiologies for end-stage liver disease (HBV, PBC...)
- •Patients with preoperative infections, infections within 48 h after transplantation or early post-operative death
结局指标
主要结局
Determine the types of early bacterial infections following LDLT, recurrent and resistant infections all were confirmed by cultures.
时间窗: Within the first 90 days after the operation
Bile, abdominal drains, blood stream infection, urinary tract infection or chest infection.
Assessment of risk factors for occurrence of recurrent bacterial infections
时间窗: The first 3 months following LDLT
Independent risk factors for infections
次要结局
未报告次要终点
研究者
Yasmine Mahmoud Aly Massoud
Lecturer of Tropical medicine
Ain Shams University