Comparative Study of Gender Identity Disorder Versus Control
- Conditions
- Gender Dysphoria, Adult
- Interventions
- Other: Psychiatric evaluations
- Registration Number
- NCT04935164
- Lead Sponsor
- Centre Hospitalier Henri Laborit
- Brief Summary
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.
- Detailed Description
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity. Gender dysphoria is accompanied by the often overwhelming need for a hormonal or even hormone-surgical transition. Gender dysphoria is very often characterized by fluctuating mood sadness, irritability, obsessionality. An improvement in the quality of life after medical treatment (hormone therapy) and gender reassignment surgery has been described in the literature. Morphological similarities have been found between the brains of women and the brains of so-called transgender women, as well as between the brains of transgender men and men. These morphological data are only very fragmentary and have not been supported by neuro-functional data. Self-awareness, which refers to the awareness that an individual has of his body, his image and his own identity, is partly underpinned, at the brain level, by the activation of the Default Mode Network (DMN) at rest, in non-pathological conditions. The conflict between the internal perception of the own body and its objective representation could result in a change in brain connectivity within the DMN, due in particular to changes in the activation of the temporo parietal junction.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
- Patients with gender dysphoria
- Without psychotropic
- Without hormono-therapy
- Without sexual surgery assignation
- Any depression
- Any addiction
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Female patients with gender dysphoria Psychiatric evaluations * female patients with gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * patients without psychotropic treatments * patients who do not benefit of hormone therapy * patients who have not yet received gender reassignment surgery * patients aged 18 to 60 years * patients with normal or corrected vision * patients without mental defect * patients without neurological impairment Male patients with gender dysphoria Psychiatric evaluations * male patients with gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * patients without psychotropic treatments * patients who do not benefit of hormone therapy * patients who have not yet received gender reassignment surgery * patients aged 18 to 60 years * patients with normal or corrected vision * patients without mental defect * patients without neurological impairment Male volunteers without gender dysphoria Psychiatric evaluations * male volunteer without gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * volunteer aged 18 to 60 years * volunteer with normal or corrected vision * volunteer without mental defect * volunteer without neurological impairment Female volunteers without gender dysphoria Psychiatric evaluations * female volunteer without gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * volunteer aged 18 to 60 years * volunteer with normal or corrected vision * volunteer without mental defect * volunteer without neurological impairment
- Primary Outcome Measures
Name Time Method Occurrence of temporal parameters of microstates C, D, E and F Week 1 to Week 24 Contribution of temporal parameters of microstates C, D, E and F Week 1 to Week 24 The proportion of the total time spent in microstates of class C,D,E and F
Mean-Global Field Power temporal parameters of microstates C, D, E and F Week 1 to Week 24 Duration of temporal parameters of microstates C, D, E and F Week 1 to Week 24 Cortical voxel activity from source reconstruction analysis, using electroencephalogram during Double Mirror Test (D.M.T). Week 1 to Week 24
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre Hospitalier Henri Laborit
🇫🇷Poitiers, France