Yoga for Cardiovascular functions

Phase 1/2

Completed

• Conditions: Hypertension

• Registration Number: CTRI/2018/08/015215
• Lead Sponsor: NA

Brief Summary

·   This is a parallel group randomized control study designed to study the effect of Bhramari pranayama on cardiovascular function and heart rate variability in patients with hypertension.

Based on the inclusion and exclusion criteria, the patients will be randomized to either study group or control group.

**Intervention:**

***Study Group:*** Subjects will be asked to perform Bhramari pranayama by inhaling through both nostrils and while exhaling should produce the sound of humming bee for the duration of 5 minutes in one day only.

***Control group:*** Subjects will be asked to sit in a comfortable posture and to inhale deeply and then while exhaling should produce the sound of ‘SSSS’ for the duration of 5 minutes in one day only.

**Assessment:**

After collecting the demographic details, the following outcome measures will be assessed before, during and immediately after the intervention.

***Cardiovascular Functions:***

The cardiovascular variables such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stoke volume (SV), cardiac output (CO), arterial stiffness and total peripheral resistant (TPR) will be assessed in sitting position using non-invasive blood pressure monitoring system (Ambulatory Blood Pressure Systems, Germany). A Non-invasive blood pressure cuff will be placed on the upper arm of the left hand at the level of the heart and the marker on the cuff will be directly above the brachial artery. The hand will be placed at the knee and flexed at the elbow.

***Heart rate variability:***

Heart rate variability will be derived from electrocardiogram taken using Holter monitoring system.

**Follow up:** Since this is study is designed to study the immediate effect, the subjects will not be followed up.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-09
• Study Completion: 2020-07-30
• Last Update Posted: 2025-04-06

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1. Subject with the history of essential hypertension 2) SBP < 180 mmHg & DBP < 110 mmHg 3) Using < 2 Anti-hypertensive medications 4) Willingness to participate in the study.

Exclusion Criteria

• 1. Subject with the history of secondary hypertension and other cardiovascular diseases like coronary artery disease, heart failure, arrhythmia, rheumatic heart diseases and congenital heart diseases.
• 5. Subject who is unable to perform Bhramari pranayama.
• 6. Subjects with irregular and frequent change of hypertensive medications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure	Baseline (5 minutes before intervention), during (intervention period) and immediately after intervention (for the period of 5 minutes)

Secondary Outcome Measures

Name	Time	Method
heart rate, Heart rate variability, stoke volume, cardiac output, arterial stiffness and total peripheral resistant	Baseline (5 minutes before intervention), during intervention (5 minutes) and immediately after intervention (for 5 minutes)

Trial Locations

Locations (1)

All India Institute of Medical Sciences; 🇮🇳 West, DELHI, India

All India Institute of Medical Sciences

🇮🇳West, DELHI, India

Dr Gautam Sharma

Principal investigator

01126549326

drgautamsharma12@gmail.com