Management of Recurrent Retroperitoneal Sarcomas: A retrospective study from a Tertiary Cancer Center.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 288
- 试验地点
- 1
- 主要终点
- Overall survival in patients with recurrent retroperitoneal sarcomas and retroperitoneal sarcoma with multiple recurrences
研究概览
简要总结
Study title: Management of Recurrent Retroperitoneal Sarcomas: A retrospective study from a Tertiary Cancer Center.
Short title: Management of Recurrent Retroperitoneal Sarcomas
Type of study: Retrospective observational study
Retroperitoneal Sarcomas (RPS) are a complex heterogenous group of relatively uncommon tumors. Owing to their complexity and rarity the optimal management of these tumours is restricted to very few dedicated high-volume centers. As a result, a large number of patients present to our center with recurrent disease. Additionally, even after optimal treatment done at high-volume centers these tumors have a high propensity for recurrence.
While there have been substantial milestones achieved in the treatment of primary RPS resulting in development of collaborative efforts, both at institutional level (in the form of dedicated RP clinics) and at internation level (in the for Transatlantic retroperitoneal sarcoma working group guidelines), there is substantial dearth of literature and consensus on the optimal strategies for management of recurrent RPS (rec RPS). It is therefore crucial to audit the outcomes of patients undergoing surgical treatment for rec RPS, in order to identify the optimal treatment strategies in terms of extent and number of re-resections and adjuvant treatment options for these patients.
This is a single center retrospective study, aims to evaluate the outcomes of rec RPS sarcomas (RPS). The results of this study are expected to answer this important question of benefit and futility of surgical excision in patients with multiple local recurrences of RPS and thereby guide optimal treatment strategies.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Consecutive adult patients (18 years and above) of both sexes with patients with Recurrent RP sarcomas.
- •Date of surgery between January 2011 to December 2024.
排除标准
- •Non-retroperitoneal, intra-abdominal sarcomas
- •Chemo-sensitive and radiosensitive histologies like Ewing’s sarcoma which have management protocols different from other RP sarcomas.
结局指标
主要结局
Overall survival in patients with recurrent retroperitoneal sarcomas and retroperitoneal sarcoma with multiple recurrences
时间窗: after surgery for first 2 years after every 3 months, then every 6 month for next 3 yrs and then every year
次要结局
- Evaluation of factors associated with multiple recurrences(after surgery for first 2 years after every 3 months, then every 6 month for next 3 yrs & then every year)
- Difference in OS between Rec RPS after adequate surgery Vs Rec RPS after inadequate surgery(after surgery for first 2 years after every 3 months, then every 6 month for next 3 yrs & then every year)
研究者
Dr Shraddha Patkar
Tata Memorial Hospital