Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance

Not Applicable

Completed

• Conditions: Obesity; Type 2 Diabetes

• Registration Number: NCT01361971
• Lead Sponsor: University of Adelaide

Brief Summary

Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin sensitivity in humans. This requires confirmation in a larger population, and with this study the investigators will also test for mechanisms how this occurs. The investigators suspect that modulation of hypoxia and stress response proteins following changes in tissue oxygenation may contribute to these improvements. This study has the potential to yield new and important insights into the insulin resistance in obesity.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04
• Study First Submitted: 2011-05-24
• Study First Submitted QC: 2011-05-26
• Study First Posted: 2011-05-27
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-17
• Last Update Posted: 2013-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Obese men with and without type 2 diabetes aged 45-70
• Lean men without type 2 diabetes aged 45-70

Exclusion Criteria

• smokers
• claustrophobic
• sleep apnoea
• blood donor
• exercise more than 2 times per week
• under certain medications eg: bleomycin,corticosteroid

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	1 year	Using Hyperinsulinemic clamp

Secondary Outcome Measures

Name	Time	Method
Hypoxia and inflammatory markers	1 year	using IHC, qPCR, Western blot

Trial Locations

Locations (1)

University of Adelaide; 🇦🇺 Adelaide, South Australia, Australia