Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Insulin sensitivity
研究概览
简要总结
Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin sensitivity in humans. This requires confirmation in a larger population, and with this study the investigators will also test for mechanisms how this occurs. The investigators suspect that modulation of hypoxia and stress response proteins following changes in tissue oxygenation may contribute to these improvements. This study has the potential to yield new and important insights into the insulin resistance in obesity.
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Obese men with and without type 2 diabetes aged 45-70
- •Lean men without type 2 diabetes aged 45-70
排除标准
- •claustrophobic
- •sleep apnoea
- •blood donor
- •exercise more than 2 times per week
- •under certain medications eg: bleomycin,corticosteroid
结局指标
主要结局
Insulin sensitivity
时间窗: 1 year
Using Hyperinsulinemic clamp
次要结局
- Hypoxia and inflammatory markers(1 year)
研究者
A/Prof Leonie Heilbronn
A/Prof
University of Adelaide