NCT01098942已完成不适用
Effects of Bariatric Surgery on Skeletal Health
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Changes in bone mineral density by dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT)
研究概览
简要总结
Bone loss may occur after bariatric (weight loss) surgery, but standard methods of measuring bone density in obese patients are potentially inaccurate. This study uses quantitative computed tomography to examine changes in bone mineral density after bariatric surgery. We are also studying mechanisms which may explain bone loss after bariatric surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Either scheduled for Roux-en-Y Gastric Bypass surgery or enrolled in a lifestyle weight management program
排除标准
- •Weight ≥ than 450 lbs
- •Postmenopausal women
- •Significant heart, kidney, liver, or malignant disease
- •Current disorders known to affect bone
- •Use of medications known to affect bone for more than 7 days in the past 12 months
结局指标
主要结局
Changes in bone mineral density by dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT)
时间窗: 1 year
次要结局
- Changes in serum and/or urine indices of bone formation and bone resorption, such as aminoterminal propeptide of type I collagen [PINP], osteocalcin, C-telopeptide cross-links [CTX])(1 year)
- Changes in bone microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT)(1 year)
研究者
Elaine W. Yu
Co-investigator
Massachusetts General Hospital
研究点 (2)
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