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Clinical Trials/NCT07561216
NCT07561216
Not yet recruiting
Not Applicable

Clinical Evaluation of Injectable Bioactive Composites Versus Resin Modified Glass Ionomer for Restoring Proximal Cavities in Primary Molars: A Randomized Clinical Tria

Cairo University0 sites50 target enrollmentStarted: May 1, 2026Last updated:
ConditionsDental Caries
InterventionsgiomerRMGI

Overview

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
50
Primary Endpoint
Secondary Caries

Overview

Brief Summary

This randomized clinical trial aims to evaluate and compare the clinical performance of injectable bioactive composite (Beautifil Flow Plus X, Shofu) versus Resin Modified Glass Ionomer (RMGI) in restoring proximal cavities (Class II) in primary molars of children aged 3-8 years over a 12-month follow-up period, using revised FDI criteria.

Detailed Description

Dental caries remains the most prevalent chronic disease in children. The choice of restorative material for primary teeth significantly impacts treatment outcomes and longevity. This study compares two fluoride-releasing restorative materials in proximal cavities of primary molars.

Eligible children aged 3-8 years with ICDAS 3 or 4 proximal carious lesions in primary molars will be randomly allocated into two equal groups (24 teeth each):

Group I (Intervention): Restoration with injectable bioactive giomer (Beautifil Flow Plus X F00, Shofu) using BeautiBond Xtreme adhesive Group II (Control): Restoration with Resin Modified Glass Ionomer (RMGI)

Restorations will be clinically evaluated at baseline, 3, 6, and 12 months using revised FDI criteria assessing biological properties (secondary caries, sensitivity, tooth integrity), functional properties (marginal adaptation, proximal contact, occlusal wear, fracture/retention), and aesthetic properties.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Masking Description

Blinding of operators, patients, parents and outcome assessors was not possible as both materials differ in appearance and application technique.

Eligibility Criteria

Ages
3 Years to 8 Years (Child)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Children aged 3-8 years of both genders
  • Cooperative behavior manageable by operators
  • Willing to sign informed consent
  • Accepts the follow-up period
  • Moderate to low caries risk according to Cariogram application
  • Posterior primary molar with proximal carious lesion (ICDAS 3 or 4) with no signs or symptoms of pulpal involvement
  • Radiographically extending to outer 1/3 of dentin

Exclusion Criteria

  • Allergy to any restorative materials
  • Patients undergoing orthodontic treatment with fixed appliances
  • Patients with debilitating systemic diseases
  • Children with special needs
  • Teeth with previous restorations
  • Periapical radiolucencies or sensitivity to percussion
  • Mobile teeth
  • External or internal resorption
  • Cervical carious lesions

Arms & Interventions

RMGIC

Active Comparator

cavity restorations in primary molars using a resin-modified glass ionomer cement. Following standard cavity preparation, the RMGI material will be placed according to the manufacturer's instructions. Clinical performance will be evaluated over the follow-up period in terms of restoration retention, marginal adaptation, secondary caries, postoperative sensitivity, and overall clinical success.

Intervention: giomer (Other)

giomer

Experimental

restoration of proximal cavities in primary molars using an injectable bioactive composite (Giomer) material. Cavities will be prepared following minimally invasive principles, isolated appropriately, and restored according to the manufacturer's instructions using adhesive bonding. Clinical performance will be evaluated in terms of retention, marginal adaptation, secondary caries, postoperative sensitivity, and overall restoration success during the follow-up period.

Intervention: RMGI (Other)

Outcomes

Primary Outcomes

Secondary Caries

Time Frame: Baseline, 3, 6, and 12 months

Assessed using revised FDI criteria (B1: caries at restoration margin). Evaluated by visual examination and short air drying. Scored on ordinal scale 1-5.

Secondary Outcomes

  • Postoperative sensitivity / pulp status(Baseline, 3, 6, and 12 months)
  • Marginal Adaptation(Baseline, 3, 6, and 12 months)
  • Proximal Contact Point(Baseline, 3, 6, and 12 months)
  • Occlusal Wear(Baseline, 3, 6, and 12 months)
  • Fracture and Retention(Baseline, 3, 6, and 12 months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Nadine elsayed Elshayal

Master's Student

Cairo University

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