Efficacy of Bitter Taste Blockers on Flavor Acceptance in Pediatric Populations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 215
- 试验地点
- 1
- 主要终点
- Proportion of subjects who rate bitter solutions with added bitter blockers as less bitter than the bitter solution alone.
研究概览
简要总结
This proposal describes 2 basic research studies that will be conducted sequentially. Study 1 will test the efficacy of both classic and newly developed "generally recognized as a safe" (GRAS) bitter blockers on the perceived bitterness and acceptance of different classes of bitter-tasting compounds by children and compare their responses to adults. Because variations among and between children and adults in terms of sensitivity to different bitter compounds are due in part to genetically determined receptor variation, the investigators will consider genotype when assessing how well bitter blockers perform. In Study 2, the investigators aim to evaluate different methods (forced-choice procedures, hedonic face scales) used for testing children to determine their reliability and reproducibility.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy, term children of either sex and all races/ethnicities will be eligible for this study.
- •Children must be between 3 and 10 years of age.
排除标准
- •Children who are on any medications that may alter taste sensitivity
- •Mothers who are pregnant
结局指标
主要结局
Proportion of subjects who rate bitter solutions with added bitter blockers as less bitter than the bitter solution alone.
时间窗: 2 hours
Primary outcome variables are the proportion of subjects by age group (children and adults) judging a variety of GRAS bitter compounds with a bitter blocker as less bitter or more pleasant than the bitter compound alone (the efficacy of the bitter blocker). At least 5 bitter compounds and 5 GRAS bitter blockers will be used. We will determine how these measures are affected by the age and genotype of the subjects.
次要结局
- Biometrics and Genotype(One year)
- Differences in bitterness ratings obtained via different pediatric taste-assessment methodologies.(2 hours)
研究者
Julie A. Mennella
Member
Monell Chemical Senses Center