Retinal and cognitive dysfunction in type 2 diabetes: unraveling the common pathways and identification of patients at risk of dementia

Completed

• Conditions: 10047060; cognitief functioneren; cognitive impairment; type 2 diabetes

• Registration Number: NL-OMON54910
• Lead Sponsor: Fundació Hospital Universitari Vall DHebron, VHIR

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-08-19

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

1. Type 2 diabetes
2. 65 years and older
3. Diabetes duration of at least 5 years
4. Mild to moderate non-proliferative diabetic retinopathy (NPDR) or with no
overt retinopathy
5. Able to provide informed consent

Exclusion Criteria

1. Previous history of stroke or neurodegenerative diseases
2. Severe NPDR, Proliferative DR (PDR), Diabetic Macular Edema (DME) or other
eye disorders affecting vision besides these complications of DR
3. Previous laser photocoagulation
4. Other diseases which may induce retinal neurodegeneration (e.g. glaucoma).
5. Subjects with a refractive error = ± 6 D.
6. Media opacities that preclude retinal imaging
7. HbA1C > 10% (86 mmol/mol)
8. Severe systemic illness or personal circumstances that would not make it
possible for the patients to fulfil study protocols

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess whether retinal sensitivity measured by microperimetry is able to<br /><br>predict cognitive decline and progression to dementia in MCI T2D patients.</p><br>