Bronchial Hyperreactivity During Histamine Passive Exposure

Not Applicable

Completed

• Conditions: Bronchial Hyperresponsiveness; Asthma
• Interventions: Drug: histamine-benzylic alcohol (magistral preparation)

• Registration Number: NCT01937494
• Lead Sponsor: Centre Hospitalier Universitaire Saint Pierre

Brief Summary

Bronchial hyperresponsiveness consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma (metacholine or histamine).Protection are used to avoid passive exposure of the technicians performing the test, despite the absence of evidence that they could develop a bronchoconstriction even if they suffer from BHR.The purpose of the study is to determine if patients with a high level of bronchial hyperreactivity and exposed passively to histamine during a bronchial challenge, are developing a bronchoconstriction, when placed in the same conditions that the technicians performing these tests.

Detailed Description

Bronchial hyperresponsiveness (BHR) consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma.BHR is also present in other diseases such as allergic rhinitis, Chronic Obstructive pulmonary disease,heart failure..

Thes test is performed with metacholine or histamine with spirometric documented response to incremental doses.Protection are used to avoid passive exposure of the technicians performing the test, despite the absence of evidence that they could develop a bronchoconstriction if they suffer from BHR.

The purpose of the study is to determine if patients, newly diagnosed with a high level of bronchial hyperreactivity and exposed passively to histamine during a bronchial challenge, are reacting to histamine when placed in the same conditions that the technicians performing these tests.

Study Timeline

• Study Start: 2013-05
• Study First Submitted: 2013-08-29
• Study First Submitted QC: 2013-09-04
• Study First Posted: 2013-09-09
• Primary Completion: 2014-05
• Study Completion: 2014-05
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-20
• Last Update Posted: 2015-02-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• adult patients with positive histamine challenge test (first dose)

Exclusion Criteria

• other active respiratory disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
asthma patients	histamine-benzylic alcohol (magistral preparation)	patients who show a positive response at the first dos of histamine challenge test will be enrolled

Primary Outcome Measures

Name	Time	Method
spirometric values in patients exposed passively to histamine during BHR challenge	1 hour

Trial Locations

Locations (1)

service de pneumologie, CHU St Pierre; 🇧🇪 Brussels, Belgium