General Anesthesia Management in 15 Preterm Infant

Completed

• Conditions: Anesthesia Management of Premature Infants
• Interventions: Other: general anesthesia management of preterm infants

• Registration Number: NCT03044366
• Lead Sponsor: Inonu University

Brief Summary

Anesthesia management of preterm infants is challenging for the anesthesiologist. Because of rudimentary build, many medical and physical problems have shown in treatment of disease such as complications, airway problems, temperature disregulation and deficient drug metabolism. This retrospective study evaluates the perioperative management and postoperative course in premature infants undergoing diode laser photocoagulation (DLP) for retinopathy of prematurity (ROP).

Detailed Description

Participants retrospectively investigate clinical data and anesthesia process of 15 preterm infant from anesthesia charts with ROP who underwent DLP between 2014 and 2016. This presented retrospective study was confirmed by the Institutional Clinical Research Ethics Board. Neonates burns under 30 weeks gestation and low birth weigh under 2000 g were admitted to the study. No infant were excluded from the study. Preterm infants were appreciated before surgery and informed consent was obtained form their parents. We recorded gestational age, American Society of Anesthesiologists (ASA) physical status scores, post-conceptual age, weight at birth and surgery, duration of anesthesia and surgery, blood glucose values at surgery, the management of airway, total hospital stay period, analgesia management, complications and comorbidities. Bradycardia ( \<90 beats/mean), desaturation (SpO2 \<90%) and arrhythmia were recorded. Electrocardiography (ECG), pulse oximetric saturation (SpO2), end-tidal carbon dioxide pressure, heart rate (HR) and body temperature were monitored in operating room. Topical 0.5% proparacaine eye drops were administered to all infants routinely. Anesthesia was induced with thiopental 6 mg kg-1 and fentanyl 1 µg kg-1 and it was maintained with 50% oxygen 50% air 1%-3% sevoflurane in all cases. Inhaled anesthetic agent was not preferred for induction of anesthesia because of causing hypotension. The premature infants were intubated by same experienced anesthesiologist. In all infants, were intubated the patients without muscle relaxant under spontaneous ventilation. Perioperative complications, blood glucose value, devices in airway management and extubation value were recorded. After surgery, extubation was performed when spontanea ventilation was enough and extubation was recorded. All infants were taken to newborn intensive care unit (NICU). Data are reported as mean ± standard deviation and percentage(%).

Study Timeline

• Study Start: 2016-12
• Study First Submitted: 2016-12-01
• Primary Completion: 2017-01
• Study Completion: 2017-01
• Status Verified: 2017-02
• Study First Submitted QC: 2017-02-02
• Study First Posted: 2017-02-07
• Last Update Submitted: 2017-02-07
• Last Update Posted: 2017-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• all preterm infants who was decided to apply ROP

Exclusion Criteria

• No patient was excluded

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Characteristics of Anesthesia management	general anesthesia management of preterm infants	Evaluate the average value of these data.
Comorbidities	general anesthesia management of preterm infants	Evaluate the average value of these data.

Primary Outcome Measures

Name	Time	Method
the management of airway	up to 2 years	the management of airway
gestational age	up to 2 years	gestational age
American Society of Anesthesiologists physical status scores	up to 2 years	American Society of Anesthesiologists physical status scores
post-conceptual age	up to 2 years	post-conceptual age
weight at birth and surgery	up to 2 years	weight at birth and surgery
duration of anesthesia and surgery	up to 2 years	duration of anesthesia and surgery

Trial Locations

Locations (1)

Inonu University Medical Faculty; 🇹🇷 Malatya, Turkey