Comparison of Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Mechanical Ventilation: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Failure
- Sponsor
- Kaohsiung Veterans General Hospital.
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- 28-day weaning success rate
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
A prospective randomized controlled trial was conducted to collect patients with prolonged mechanical ventilation. Patients were randomly assigned to receive PAV+ or PSV as weaning mode. Weaning outcomes were compared between 2 groups.
Detailed Description
Pressure support ventilation (PSV) the most frequently used mode of ventilator support in intensive care units, but has several demerits. Proportional assist ventilation with load-adjustable gain factors (PAV+) is a promising mode with better patient synchrony and weaning advantages. However, weaning outcome of PAV+ in patients with prolonged mechanical ventilation has not been evaluated before. We conducted a prospective randomized controlled trial in a tertiary medical center. This study aimed to compare the effectiveness between PAV+ and PSV for weaning adult patients with prolonged mechanical ventilation.
Investigators
Chiu-Fan Chen
Principal Investigator
Kaohsiung Veterans General Hospital.
Eligibility Criteria
Inclusion Criteria
- •Patients with prolonged mechanical ventilation and transfer to respiratory care center, age of 20 years or older, at least 1 time of extubation failure or spontaneous breathing trial failure in ICU, stable hemodynamics, no vasopressor use, FiO2 = 0.40 or less, external positive end-expiratory pressure = 5 cmH2O or less, PaO2 \> 60 mmHg, and body temperature \< 38ºC (within 24 hours).
Exclusion Criteria
- •Patients with bronchopleural fistulas, central neurological disorders, hemodialysis, and those with pressure support level already \< 15 cmH2O.
Outcomes
Primary Outcomes
28-day weaning success rate
Time Frame: 28 days
Weaning success was defined as being alive and liberation from MV for more than 48 hours.
Secondary Outcomes
- Weaning duration(up to 28 days)
- Weaning success at discharge(up to 123 days)
- Hospital length of stay(up to 123 days)
- Hospital mortality(up to 123 days)