Tenecteplase versus Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK)

Phase 2

• Conditions: Ischemic Stroke; Stroke - Ischaemic

• Registration Number: ACTRN12615000220561
• Lead Sponsor: euroscience Trials Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-03-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1. Patients presenting with acute ischemic stroke eligible using
standard criteria to receive IV thrombolysis within 4.5 hours
of stroke onset
2. Patient is 18 years or older
3. Intra-arterial clot retrieval treatment can commence (groin
puncture) within 6 hours of stroke onset.
Imaging inclusion criteria
Dual target:
5. Arterial occlusion on CT angiography of the internal carotid, middle cerebral (M1/M2 segments) or basilar artery
6. Mismatch (only applies to anterior circulation)- Using CT perfusion with a Tmax >6 second delay perfusion volume and CT-rCBF ischemic core volume.
a) Mismatch ratio of greater than 1.2, and
b) Absolute mismatch volume of greater than 10 ml, and.
c) Ischemic core lesion volume of less than 70m

Exclusion Criteria

1. Intracranial hemorrhage (ICH) identified by CT
2. Rapidly improving symptoms at the discretion of the
investigator
3. Pre-stroke mRS score of >=4 (indicating previous disability)
4. Hypodensity in >1/3 MCA territory or equivalent proportion
of basilar artery territory on non-contrast CT
5. Contra indication to imaging with contrast agents
6. Any terminal illness such that patient would not be expected
to survive more than 1 year
7. Any condition that, in the judgment of the investigator could
impose hazards to the patient if study therapy is initiated or
affect the participation of the patient in the study.
8. Pregnant women

Study & Design

• Study Type: Interventional
• Study Design: Not specified