A Research on the Hospital Pollution Control and Hygine Intervention of Chemotherapy Drugs Exposure

• Conditions: Sister-chromatic-exchange(SCE); Micronuclei(MN)

• Registration Number: NCT01253057
• Lead Sponsor: Taipei Medical University WanFang Hospital

Brief Summary

Several epidemiological studies found that exposure to antineoplastic agents were associated with some reproductive, carcinogenic effects, higher rates of advance micronuclei (MN), sister-chromatic-exchange (SCE) and spontaneous abortion. Cleaning staff were potentially exposed to these agents while cleaning ward, ward toilet or other area.

One medical center and one area hospitals in Taipei.Surface wipe samples were collected in the cleaning staff work area, such as ward environment and ward toilet. Urine and blood samples of subjects were collected for exposure examinations. Platinum-containing drugs (Cisplatin, Carboplatin, Oxaliplatin) were used as indicator drugs in environmental (surface wipe samples) and biological (urine and blood samples) samples.

A self-administered questionnaire was used to collect demographic data, working practices, medical and contact history, and perceived work-related symptoms of cleaning staff.

The results of this study will be to reduce exposure to cleaning staff.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10
• Status Verified: 2010-12
• Study First Submitted: 2010-12-01
• Study First Submitted QC: 2010-12-01
• Last Update Submitted: 2010-12-01
• Study First Posted: 2010-12-03
• Last Update Posted: 2010-12-03
• Study Completion: 2011-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Only included those who signed the consent study

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Taipei Medical University WanFang Hospital; 🇨🇳 Taipei, Taiwan