Effect of mesenchimal stem cell in knee osteoarthritis
Phase 2
- Conditions
- Primary knee osteoarthrosis, bilateral.Primary knee osteoarthrosis, bilateralM17.0
- Registration Number
- IRCT20151017024572N19
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Patients with mild to moderate OA of the knee (Kellgren Lawrence grade I, II and III)
Knee pain for at least six months
Age 18 to 75 years old
The absence of any acute or chronic infection
No pregnancy or lack of planning to get pregnant
No history of any intra articular knee injection in three months ago
The absence of inflammatory articular disease or secondary osteoarthritis
No history of knee surgery
No severe underlying disease such as uncontrolled diabetes,Use of anticoagulants
Lack of daily use of opioid and non opioid analgesics
Exclusion Criteria
The willingness of patients to exit from the study at any stage of the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The severity of pain. Timepoint: Zero, two weeks, one and six months after. Method of measurement: Visual Analog Scale(VAS).;The severity of symptoms and functional limitations. Timepoint: Zero, two weeks, one and six months after. Method of measurement: By using WOMAC questionnare.;Range of motion. Timepoint: Zero, two weeks, one and six months after. Method of measurement: Goniometer.
- Secondary Outcome Measures
Name Time Method Side effects. Timepoint: two and four weeks after. Method of measurement: Physical examination.