COMPARISION OF PAIN PERCEIVED BETWEEN TWO LOCAL ANAESTHETICS FOR ROOT CANAL TREATMENT OF ADULTS.

Completed

• Conditions: Pulpitis,

• Registration Number: CTRI/2022/10/046800
• Lead Sponsor: Dr Vaishnavi Patankar

Brief Summary

Pain during dental treatment is a common fear of patients, which can be controlled successfully by different formulations and techniques of local anaesthetics. Articaine is an amide local anaesthetic solution that substitutes a thiophene ring for the benzene ring present in lidocaine which allows Articaine molecules to diffuse through nerve membranes more effectively than lidocaine molecules, due to increased lipid solubility, resulting in more efficient anaesthesia. Several randomized clinical trials have reported that Articaine is more effective than lidocaine in achieving profound dental pulp anaesthesia particularly following infiltration in the maxilla and as a supplementary infiltration following inferior alveolar nerve block (IANB) in the mandible. Clinical data confirmed that the addition of sodium bicarbonate in local anaesthetics reduces pain, decreases onset and increases duration of local anaesthesia, as compared to local anaesthetic without it. Buffering local anaesthetic formulations increases the pH, making the formulation closer to physiologic pH which results in elimination of injection burning and pain, reduces direct tissue irritation caused by infiltration of a more acidic compound. Once buffered, the anaesthetic formulation will have a higher pH upon injection and more deionized base form will be available to penetrate the nerve sheath and provide anaesthesia even in cases of infection. Hence this study is designed to evaluate pain perception during Local Anaesthetic delivery and Anaesthetic Efficacy of 4% Articaine and 4% Buffered Articaine in Permanent Maxillary Molar Buccal Infiltration in patients with symptomatic irreversible pulpitis.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-11
• Study Completion: 2023-10-26
• Last Update Posted: 2024-03-24

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients older than 18 years and younger than 60 years of either gender.
• Patients who have symptomatic irreversible pulpitis and indicated for root canal treatment.
• Cooperative healthy patients who are willing to participate in the study and sign the consent form.

Exclusion Criteria

• Patients younger than 18 or older than 60 years.
• Subjects taking any medication such as analgesics, narcotics, sedatives, or antidepressants that may affect anaesthetic assessment.
• History of unstable cardiovascular diseases, diabetes, hypertension, pregnancy, asthma, allergies to local anaesthetics, bleeding disorders, neurological conditions.
• Subjects unable to give informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The pain scores (VAS) with conventional Articaine and buffered Articaine.	At baseline, immediately after injection

Secondary Outcome Measures

Name	Time	Method
Onset of action of local anaesthesia	Onset of action of local anaesthesia will be checked 30 seconds after administering injection with the help of electric pulp test.

Trial Locations

Locations (1)

Bharati Vidyapeeth Dental College and Hospital Sector 7 CBD Belapur Navi Mumbai; 🇮🇳 Thane, MAHARASHTRA, India

Bharati Vidyapeeth Dental College and Hospital Sector 7 CBD Belapur Navi Mumbai

🇮🇳Thane, MAHARASHTRA, India

Dr Vaishnavi Patankar

Principal investigator

9766820931

vaishnavipatankar597@gmail.com