The Relationship Between Pseudoexfoliation and Chronic Kidney Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 358
- Locations
- 1
- Primary Endpoint
- Prevalance of pseudoexfoliation in patients with chronic kidney disease
Study Overview
Brief Summary
Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.
Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 40 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •All patients with chronic kidney disease stage 1-5
Exclusion Criteria
- •History of eye trauma or surgery
Outcomes
Primary Outcomes
Prevalance of pseudoexfoliation in patients with chronic kidney disease
Time Frame: 7 months
Secondary Outcomes
No secondary outcomes reported
Investigators
Leyla Niyaz
Ophthalmology Specialist
Corum State Hospital