Pseudoexfoliation and Chronic Kidney Disease

Completed

• Conditions: Chronic Kidney Disease

• Registration Number: NCT01693744
• Lead Sponsor: Corum State Hospital

Brief Summary

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10
• Study Completion: 2012-04
• Status Verified: 2012-09
• Study First Submitted: 2012-09-20
• Study First Submitted QC: 2012-09-24
• Last Update Submitted: 2012-09-24
• Study First Posted: 2012-09-26
• Last Update Posted: 2012-09-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 358

Inclusion Criteria

• All patients with chronic kidney disease stage 1-5

Exclusion Criteria

• History of eye trauma or surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalance of pseudoexfoliation in patients with chronic kidney disease	7 months

Trial Locations

Locations (1)

Corum State Hospital; 🇹🇷 Corum, Turkey