Ejaculation Frequency and Semen Parameters
- Conditions
- FertilitySperm
- Registration Number
- NCT06172504
- Lead Sponsor
- The First Hospital of Jilin University
- Brief Summary
The goal of this observational study is to determine whether the frequency of ejaculation in men had an effect on semen parameters.. The main questions it aims to answer are:
* question 1：Whether the frequency of ejaculation has an effect on semen parameters
* question 2：Whether the penultimate abstinence period has an effect on semen parameters
The participants were men who underwent semen examination in the andrology clinic of the Reproductive Center of the First Hospital of Jilin University. A brief medical history was collected from each volunteer, including demographic information, fertility history and as well as information regarding their general health.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month.
- Detailed Description
The main subjects of this study were husbands who underwent semen examination, Including pre-conception, infertility, and his wife with a history of pregnancy loss. Before the examination, the basic information such as age, height, weight, smoking, drinking, infertility years, fertility and pregnancy history, marriage years, education, occupation and exclusion criteria have adverse effects on sperm were investigated.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month. According to World Health Organization standards, semen analysis requires abstinence for 48h to 7 days. Semen parameters were recorded, including sperm DNA fragmentation rate, sperm motility rate, total sperm count, sperm motility, and sperm morphology. The frequency of ejaculation was divided into four groups:(1)0-4 times/month;(2)5-8 times/month;(3) 8-12 times/month;(4) \>12 times/month.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Male
- Target Recruitment
- 1500
- Normal ejaculation function, normal sexual life, masturbation can ejaculate
- Male age between 22 and 45 years old.
- According to World Health Organization standards, the semen examination time is within 48h to 7 days of abstinence.
- The man was diagnosed with extremely severe oligospermia (sperm concentration <1 million/ml) and azoospermia.
- Identify the factors affecting semen parameters, long-term exposure to high temperature, long-term exposure to chemicals, heavy metals, radiation and other toxic and harmful substances, orchitis/epididymitis, cryptorchidism, radiotherapy and chemotherapy treatment, and taking drugs to improve sperm within three months
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect of ejaculation frequency on sperm DNA fragmentation rate 6 months The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm DNA fragment rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month.The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on sperm motility rate 6 months The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm motility rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on total sperm count 6 months The subjects abstained for 3-7 days and masturbated to collect semen for measurement of total sperm count. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on sperm vitality rate 6 months The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm vitality rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
Effect of ejaculation frequency on sperm morphology 6 months The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm morphology. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups
- Secondary Outcome Measures
Name Time Method Effect of the penultimate abstinence period on DNA fragmentation rate 6 months The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm morphology. Survey the basic information of the subjects and their penultimate abstinence period. The outcome was to compare whether the penultimate abstinence period had an effect on DNA fragmentation rate（the cutoff value is 15%). We plans to recruit more than 1000 subjects.
Trial Locations
- Locations (1)
the first hospital of Jilin University
🇨🇳Changchun, Jilin, China