Basophil Activation Test cow's milk for replacement of the food challenge test - BAT cow's milk for replacement of the food challenge test.

Rijnstate Ziekenhuis0 个研究点目标入组 700 人开始时间: 待定最近更新: 2024年4月9日

试验速览

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•Inclusion criteria (all criteria must be met with in b. one or more symptoms):
•a. Age 0-12 years
•b. Suspected of cow's milk allergy with one or more of the following complaints
•after intake of cow's milk:
•- angioedema
•- urticaria
•- sneezing and rhinitis <2 hours after feeding
•- sensation of swelling in the throat and/or difficulty swallowing <2 hours
•after feeding
•- voice change/hoarseness <2 hours after feeding
•- cough <2 hours after feeding
•- wheezing and/or shortness of breath <2 hours after feeding
•- loss of consciousness <2 hours after feeding
•- vomiting or abdominal pain or diarrhoea <2 hours after feeding in children <4
•years only in combination with IgE-mediated complaints in other tracts
•c. Placed on a waiting list for a hospital food challenge test
•d. Blood draw for cow*s milk sIgE and BAT < 3 months before the food challenge
•e. Signed informed consent parents/guardians

•Exclusion criteria (if one or more criteria are met, the child will be
•a. Age > 12 years
•b. Suspicion of Food Protein-Induced Enterocolitis Syndrome (FPIES)
•c. Eosinophilic esophagitis due to a cow's milk allergy
•d. Suspected cow's milk allergy <4 years with crying and/or agitation and/or
•eczema and/or abdominal pain and/or failure to
•thrive and/or blood loss per anum and/or diarrhoea and/or reflux and/or
•vomiting as the only manifestation of the allergy without
•IgE-mediated symptoms in another organ system
•e. Systemic immunosuppressant use
•f. Other underlying chronic conditions (immunological, oncological, chromosomal
•abnormalities).

发起方

Rijnstate Ziekenhuis