Association Between Multiple Coagulation-related Factors and Lymph Node Metastasis in Patients With Gastric Cancer: A Retrospective Cohort Study

Recruiting

• Conditions: Lymph Node Metastasis; Gastric Cancer Stage
• Interventions: Diagnostic Test: coagulation-related factors

• Registration Number: NCT05592925
• Lead Sponsor: Shandong Provincial Hospital

Brief Summary

We initially selected a total of 1128 patients with primary gastric cancer who presented at Shandong Provincial Hospital between January 2018 and October 2022, and retrospectively collected their clinical and pathological data. And retrospectively analyzed preoperative baseline characteristics, preoperative laboratory tests, and postoperative pathological results for these patients

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Status Verified: 2022-10
• Study First Submitted: 2022-10-18
• Study First Submitted QC: 2022-10-21
• Last Update Submitted: 2022-10-21
• Study First Posted: 2022-10-25
• Last Update Posted: 2022-10-25
• Primary Completion: 2022-10-31
• Study Completion: 2022-10-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 516

Inclusion Criteria

1. patients with primary gastric malignant tumors,
2. patients who underwent radical resection of gastric cancer,
3. patients with a postoperative pathology of adenocarcinoma or signet ring cell carcinoma according to the WTO pathological classification,

Exclusion Criteria

1. patients who have distant metastases, such as liver or lung metastases, were found on preoperative ultrasound and computed tomography (CT) examinations,
2. patients who have received preoperative neoadjuvant chemotherapy,
3. patients who take anticoagulant drugs (such as aspirin) prior to surgery,
4. patients who had any previous coagulation disorder.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
N0	coagulation-related factors	gastric cancer patients with no lymph node metastasis
N+	coagulation-related factors	gastric cancer patients with lymph node metastasis, including patients with N1, N2 and N3 stage cancer

Primary Outcome Measures

Name	Time	Method
Preoperative coagulation-related factors (fibrinogen levels) of patients	Three years	Fibrinogen levels (g/L). Measure the data of preoperative fibrinogen levels in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.
Preoperative coagulation-related factors (MA values) of patients	Three years	MA values(mm). Measure the data of preoperative MA values in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.
Preoperative coagulation-related factors (platelet counts) of patients	Three years	Platelet counts（x10\^9/L). Measure the data of preoperative platelet counts in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.
Preoperative coagulation-related factors (D-dimer) of patients	Three years	D-dimer (mg/L). Measure the data of preoperative D-dimer in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.
Postoperative pathological results of tumor N stage.	Three years.	Recording the postoperative pathological tumor N stage in 516 patients with gastric cancer.
Postoperative pathological results of tumor T stage.	Three years	Recording the postoperative pathological tumor T stage in 516 patients with gastric cancer.

Trial Locations

Locations (1)

Shandong Provincial Hospital; 🇨🇳 Jinan, Shandong, China